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Aerosolized antifungals for the prevention and treatment of invasive fungal infections

Publication ,  Journal Article
Dimondi, VP; Drew, RH
Published in: Current Fungal Infection Reports
June 1, 2013

Invasive fungal infections result in significant morbidity and mortality, most notably in immunosuppressed patients. Aerosolized antifungal agents have been utilized primarily as prophylaxis (either alone or in combination with systemic antifungals) in patients at highest risk of invasive infections in attempts to optimize drug delivery while minimizing the potential for systemic toxicity and/or drug interactions. Published clinical experience with aerosolized antifungals most frequently involves various formulations of the polyene amphotericin B in patients undergoing lung transplantation and/or select patients with hematologic malignancy. Adverse events are infrequent and generally limited to dyspnea, dysgeusia, and cough. Existing data suggests lipid-based amphotericin B formulations may be better tolerated than amphotericin B deoxycholate. Published clinical experience with aerosolized antifungals as adjunctive treatment of invasive fungal infections is limited to case reports. Currently, there is insufficient evidence to support use of aerosolized echinocandins and azoles in clinical practice. Outstanding questions regarding comparative efficacy, optimal dose, duration and drug delivery present a continuing challenge when utilizing these agents in clinical practice. © 2013 Springer Science+Business Media New York.

Duke Scholars

Published In

Current Fungal Infection Reports

DOI

EISSN

1936-377X

ISSN

1936-3761

Publication Date

June 1, 2013

Volume

7

Issue

2

Start / End Page

110 / 118

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences
 

Citation

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Dimondi, V. P., & Drew, R. H. (2013). Aerosolized antifungals for the prevention and treatment of invasive fungal infections. Current Fungal Infection Reports, 7(2), 110–118. https://doi.org/10.1007/s12281-013-0137-y
Dimondi, V. P., and R. H. Drew. “Aerosolized antifungals for the prevention and treatment of invasive fungal infections.” Current Fungal Infection Reports 7, no. 2 (June 1, 2013): 110–18. https://doi.org/10.1007/s12281-013-0137-y.
Dimondi VP, Drew RH. Aerosolized antifungals for the prevention and treatment of invasive fungal infections. Current Fungal Infection Reports. 2013 Jun 1;7(2):110–8.
Dimondi, V. P., and R. H. Drew. “Aerosolized antifungals for the prevention and treatment of invasive fungal infections.” Current Fungal Infection Reports, vol. 7, no. 2, June 2013, pp. 110–18. Scopus, doi:10.1007/s12281-013-0137-y.
Dimondi VP, Drew RH. Aerosolized antifungals for the prevention and treatment of invasive fungal infections. Current Fungal Infection Reports. 2013 Jun 1;7(2):110–118.
Journal cover image

Published In

Current Fungal Infection Reports

DOI

EISSN

1936-377X

ISSN

1936-3761

Publication Date

June 1, 2013

Volume

7

Issue

2

Start / End Page

110 / 118

Related Subject Headings

  • 3207 Medical microbiology
  • 3202 Clinical sciences