Crystallographic model validation: from diagnosis to healing.
Journal Article (Review)
Model validation has evolved from a passive final gatekeeping step to an ongoing diagnosis and healing process that enables significant improvement of accuracy. A recent phase of active development was spurred by the worldwide Protein Data Bank requiring data deposition and establishing Validation Task Force committees, by strong growth in high-quality reference data, by new speed and ease of computations, and by an upswing of interest in large molecular machines and structural ensembles. Progress includes automated correction methods, concise and user-friendly validation reports for referees and on the PDB websites, extension of error correction to RNA and error diagnosis to ligands, carbohydrates, and membrane proteins, and a good start on better methods for low resolution and for multiple conformations.
Full Text
Duke Authors
Cited Authors
- Richardson, JS; Prisant, MG; Richardson, DC
Published Date
- October 2013
Published In
Volume / Issue
- 23 / 5
Start / End Page
- 707 - 714
PubMed ID
- 24064406
Pubmed Central ID
- 24064406
Electronic International Standard Serial Number (EISSN)
- 1879-033X
Digital Object Identifier (DOI)
- 10.1016/j.sbi.2013.06.004
Language
- eng
Conference Location
- England