Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1.

Published online

Journal Article

By conveying signals from the small GTPase family of proteins to the Arp2/3 complex, proteins of the WAVE family facilitate actin remodeling. The WAVE-1 isoform is expressed at high levels in brain, where it plays a role in normal synaptic processing, and is implicated in hippocampus-dependent memory retention. We used electron microscopy to determine whether synaptic structure is modified in the hippocampus of WAVE-1 knockout mice, focusing on the neuropil of CA1 stratum radiatum. Mice lacking WAVE-1 exhibited alterations in the morphology of both axon terminals and dendritic spines; the relationship between the synaptic partners was also modified. The abnormal synaptic morphology we observed suggests that signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus.

Full Text

Duke Authors

Cited Authors

  • Hazai, D; Szudoczki, R; Ding, J; Soderling, SH; Weinberg, RJ; Sótonyi, P; Rácz, B

Published Date

  • 2013

Published In

Volume / Issue

  • 8 / 9

Start / End Page

  • e75248 -

PubMed ID

  • 24086480

Pubmed Central ID

  • 24086480

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0075248

Language

  • eng

Conference Location

  • United States