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Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay.

Publication ,  Journal Article
Kim, SJ; Sohn, I; Do, I-G; Jung, SH; Ko, YH; Yoo, HY; Paik, S; Kim, WS
Published in: Ann Hematol
March 2014

We performed the whole genome cDNA-mediated annealing, selection and ligation assay with 164 formalin-fixed paraffin-embedded (FFPE) tumor samples to develop robust prognostic gene expression profiles in patients with diffuse large B cell lymphoma. The prognostic gene expression profiles were developed and validated by a gradient lasso and leave-one-out cross-validation process. We identified a set of genes whose expression provided prognostic indicators from whole data set (PRKCDBP, CASP10, FAM3C, KCNK12, MAN1A2, PRND, RAB1A, TMEM39B, SLC6A6, MMP12, FEM1B, C3orh37, RBP1, HK1, LOC400464, KIAA0746, and SLC25A23). This gene expression profile-based risk model could classify patients into two cross-validated risk groups with a significant difference in 5-year progression-free survival rates (71.1 vs. 45.5 %) and with a hazard ratio for recurrence of 2.45 (95 % CI, 1.44-4.16, P = 0.001). This model provided prognostic information independent of the International Prognostic Index (IPI), and discriminated high-risk group from patients belong to high/high-intermediate risk of IPI and activated B cell-like type. Thus, gene expression profiling from FFPE could provide additional prognostic information for diffuse large B cell lymphoma and our data underscore the need for development of risk-adapted treatment strategies based on gene expression profiles.

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Published In

Ann Hematol

DOI

EISSN

1432-0584

Publication Date

March 2014

Volume

93

Issue

3

Start / End Page

437 / 447

Location

Germany

Related Subject Headings

  • Young Adult
  • Survival Analysis
  • Retrospective Studies
  • RNA, Neoplasm
  • Proteomics
  • Prognosis
  • Oligonucleotide Array Sequence Analysis
  • Neoplasm Staging
  • Neoplasm Proteins
  • Middle Aged
 

Citation

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Kim, S. J., Sohn, I., Do, I.-G., Jung, S. H., Ko, Y. H., Yoo, H. Y., … Kim, W. S. (2014). Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay. Ann Hematol, 93(3), 437–447. https://doi.org/10.1007/s00277-013-1884-0
Kim, Seok Jin, Insuk Sohn, In-Gu Do, Sin Ho Jung, Young Hyeh Ko, Hae Yong Yoo, Soonmyung Paik, and Won Seog Kim. “Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay.Ann Hematol 93, no. 3 (March 2014): 437–47. https://doi.org/10.1007/s00277-013-1884-0.
Kim SJ, Sohn I, Do I-G, Jung SH, Ko YH, Yoo HY, et al. Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay. Ann Hematol. 2014 Mar;93(3):437–47.
Kim, Seok Jin, et al. “Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay.Ann Hematol, vol. 93, no. 3, Mar. 2014, pp. 437–47. Pubmed, doi:10.1007/s00277-013-1884-0.
Kim SJ, Sohn I, Do I-G, Jung SH, Ko YH, Yoo HY, Paik S, Kim WS. Gene expression profiles for the prediction of progression-free survival in diffuse large B cell lymphoma: results of a DASL assay. Ann Hematol. 2014 Mar;93(3):437–447.
Journal cover image

Published In

Ann Hematol

DOI

EISSN

1432-0584

Publication Date

March 2014

Volume

93

Issue

3

Start / End Page

437 / 447

Location

Germany

Related Subject Headings

  • Young Adult
  • Survival Analysis
  • Retrospective Studies
  • RNA, Neoplasm
  • Proteomics
  • Prognosis
  • Oligonucleotide Array Sequence Analysis
  • Neoplasm Staging
  • Neoplasm Proteins
  • Middle Aged