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Antipsychotic Drugs

Publication ,  Journal Article
McEvoy, JP
January 1, 2009

All antipsychotic drugs decrease dopamine neurotransmission. The conventional neuroleptic drugs block dopamine D2 receptors, leading to a gradual reduction of acute psychotic features and the prevention of relapse; they produce coarse neurological side effects at excessive doses. Clozapine was the first atypical antipsychotic in that it did not produce neurological side effects; it also produced greater therapeutic benefit than did the conventional neuroleptics. The newer atypical antipsychotic drugs add antagonism at type 2 serotonin receptors to D2 antagonism, and produce less neurological side effects; however, some of these drugs produce substantial weight gain, and elevations in lipids and insulin resistance. © 2009 Elsevier Ltd All rights reserved.

Duke Scholars

DOI

Publication Date

January 1, 2009

Start / End Page

487 / 492
 

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McEvoy, J. P. (2009). Antipsychotic Drugs, 487–492. https://doi.org/10.1016/B978-008045046-9.00375-2
McEvoy, J. P. “Antipsychotic Drugs,” January 1, 2009, 487–92. https://doi.org/10.1016/B978-008045046-9.00375-2.
McEvoy JP. Antipsychotic Drugs. 2009 Jan 1;487–92.
McEvoy, J. P. Antipsychotic Drugs. Jan. 2009, pp. 487–92. Scopus, doi:10.1016/B978-008045046-9.00375-2.
McEvoy JP. Antipsychotic Drugs. 2009 Jan 1;487–492.

DOI

Publication Date

January 1, 2009

Start / End Page

487 / 492