Land use and land cover (LULC) is now recognized as an important driver of disease. For emerging or re-emerging infectious diseases, LULC offers context and serves as a likely proximate driver of risk particularly when considering vector-borne or zoonotic diseases. Ontological differences embedded within disciplinary structures impede progress limiting the ultimate potential of both LULC data and land change theory within disease research. Geography, space, and time serve as effective complements to traditional health and place organizational and disease-research strategies. Improved systemic clarity is obtained if one orients the disease relationship to particular contexts and if the scales of the relationships are clearly defined. © 2013.