An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association.


Journal Article

Despite the global impact and advances in understanding the pathophysiology of cerebrovascular diseases, the term "stroke" is not consistently defined in clinical practice, in clinical research, or in assessments of the public health. The classic definition is mainly clinical and does not account for advances in science and technology. The Stroke Council of the American Heart Association/American Stroke Association convened a writing group to develop an expert consensus document for an updated definition of stroke for the 21st century. Central nervous system infarction is defined as brain, spinal cord, or retinal cell death attributable to ischemia, based on neuropathological, neuroimaging, and/or clinical evidence of permanent injury. Central nervous system infarction occurs over a clinical spectrum: Ischemic stroke specifically refers to central nervous system infarction accompanied by overt symptoms, while silent infarction by definition causes no known symptoms. Stroke also broadly includes intracerebral hemorrhage and subarachnoid hemorrhage. The updated definition of stroke incorporates clinical and tissue criteria and can be incorporated into practice, research, and assessments of the public health.

Full Text

Duke Authors

Cited Authors

  • Sacco, RL; Kasner, SE; Broderick, JP; Caplan, LR; Connors, JJB; Culebras, A; Elkind, MSV; George, MG; Hamdan, AD; Higashida, RT; Hoh, BL; Janis, LS; Kase, CS; Kleindorfer, DO; Lee, J-M; Moseley, ME; Peterson, ED; Turan, TN; Valderrama, AL; Vinters, HV; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia, ; Council on Cardiovascular Radiology and Intervention, ; Council on Cardiovascular and Stroke Nursing, ; Council on Epidemiology and Prevention, ; Council on Peripheral Vascular Disease, ; Council on Nutrition, Physical Activity and Metabolism,

Published Date

  • July 2013

Published In

Volume / Issue

  • 44 / 7

Start / End Page

  • 2064 - 2089

PubMed ID

  • 23652265

Pubmed Central ID

  • 23652265

Electronic International Standard Serial Number (EISSN)

  • 1524-4628

Digital Object Identifier (DOI)

  • 10.1161/STR.0b013e318296aeca


  • eng

Conference Location

  • United States