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The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study.

Publication ,  Journal Article
Urbanek, M; Hayes, MG; Armstrong, LL; Morrison, J; Lowe, LP; Badon, SE; Scheftner, D; Pluzhnikov, A; Levine, D; Laurie, CC; McHugh, C; Guo, C ...
Published in: Hum Mol Genet
September 1, 2013

Newborns characterized as large and small for gestational age are at risk for increased mortality and morbidity during the first year of life as well as for obesity and dysglycemia as children and adults. The intrauterine environment and fetal genes contribute to the fetal size at birth. To define the genetic architecture underlying the newborn size, we performed a genome-wide association study (GWAS) in 4281 newborns in four ethnic groups from the Hyperglycemia and Adverse Pregnancy Outcome Study. We tested for association with newborn anthropometric traits (birth length, head circumference, birth weight, percent fat mass and sum of skinfolds) and newborn metabolic traits (cord glucose and C-peptide) under three models. Model 1 adjusted for field center, ancestry, neonatal gender, gestational age at delivery, parity, maternal age at oral glucose tolerance test (OGTT); Model 2 adjusted for Model 1 covariates, maternal body mass index (BMI) at OGTT, maternal height at OGTT, maternal mean arterial pressure at OGTT, maternal smoking and drinking; Model 3 adjusted for Model 2 covariates, maternal glucose and C-peptide at OGTT. Strong evidence for association was observed with measures of newborn adiposity (sum of skinfolds model 3 Z-score 7.356, P = 1.90×10⁻¹³, and to a lesser degree fat mass and birth weight) and a region on Chr3q25.31 mapping between CCNL and LEKR1. These findings were replicated in an independent cohort of 2296 newborns. This region has previously been shown to be associated with birth weight in Europeans. The current study suggests that association of this locus with birth weight is secondary to an effect on fat as opposed to lean body mass.

Duke Scholars

Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

September 1, 2013

Volume

22

Issue

17

Start / End Page

3583 / 3596

Location

England

Related Subject Headings

  • White People
  • Thailand
  • Serine Peptidase Inhibitor Kazal-Type 5
  • Racial Groups
  • Proteinase Inhibitory Proteins, Secretory
  • Pregnancy
  • Mexican Americans
  • Male
  • Linear Models
  • Infant, Newborn
 

Citation

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Urbanek, M., Hayes, M. G., Armstrong, L. L., Morrison, J., Lowe, L. P., Badon, S. E., … HAPO Study Cooperative Research Group, . (2013). The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. Hum Mol Genet, 22(17), 3583–3596. https://doi.org/10.1093/hmg/ddt168
Urbanek, Margrit, M Geoffrey Hayes, Loren L. Armstrong, Jean Morrison, Lynn P. Lowe, Sylvia E. Badon, Doug Scheftner, et al. “The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study.Hum Mol Genet 22, no. 17 (September 1, 2013): 3583–96. https://doi.org/10.1093/hmg/ddt168.
Urbanek M, Hayes MG, Armstrong LL, Morrison J, Lowe LP, Badon SE, et al. The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. Hum Mol Genet. 2013 Sep 1;22(17):3583–96.
Urbanek, Margrit, et al. “The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study.Hum Mol Genet, vol. 22, no. 17, Sept. 2013, pp. 3583–96. Pubmed, doi:10.1093/hmg/ddt168.
Urbanek M, Hayes MG, Armstrong LL, Morrison J, Lowe LP, Badon SE, Scheftner D, Pluzhnikov A, Levine D, Laurie CC, McHugh C, Ackerman CM, Mirel DB, Doheny KF, Guo C, Scholtens DM, Dyer AR, Metzger BE, Reddy TE, Cox NJ, Lowe WL, HAPO Study Cooperative Research Group. The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. Hum Mol Genet. 2013 Sep 1;22(17):3583–3596.
Journal cover image

Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

September 1, 2013

Volume

22

Issue

17

Start / End Page

3583 / 3596

Location

England

Related Subject Headings

  • White People
  • Thailand
  • Serine Peptidase Inhibitor Kazal-Type 5
  • Racial Groups
  • Proteinase Inhibitory Proteins, Secretory
  • Pregnancy
  • Mexican Americans
  • Male
  • Linear Models
  • Infant, Newborn