Skip to main content

Hyperthermia as adjunct to intravesical chemotherapy for bladder cancer.

Publication ,  Journal Article
Owusu, RA; Abern, MR; Inman, BA
Published in: Biomed Res Int
2013

Nonmuscle invasive bladder cancer remains a very costly cancer to manage because of high recurrence rates requiring long-term surveillance and treatment. Emerging evidence suggests that adjunct and concurrent use of hyperthermia with intravesical chemotherapy after transurethral resection of bladder tumor further reduces recurrence risk and progression to advanced disease. Hyperthermia has both direct and immune-mediated cytotoxic effect on tumor cells including tumor growth arrest and activation of antitumor immune system cells and pathways. Concurrent heat application also acts as a sensitizer to intravesical chemotherapy agents. As such the ability to deliver hyperthermia to the focus of tumor while minimizing damage to surrounding benign tissue is of utmost importance to optimize the benefit of hyperthermia treatment. Existing chemohyperthermia devices that allow for more localized heat delivery continue to pave the way in this effort. Current investigational methods involving heat-activated drug delivery selectively to tumor cells using temperature-sensitive liposomes also offer promising ways to improve chemohyperthermia efficacy in bladder cancer while minimizing toxicity to benign tissue. This will hopefully allow more widespread use of chemohyperthermia to all bladder cancer patients, including metastatic bladder cancer.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Biomed Res Int

DOI

EISSN

2314-6141

Publication Date

2013

Volume

2013

Start / End Page

262313

Location

United States

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Urinary Bladder
  • Temperature
  • Hyperthermia, Induced
  • Humans
  • Drug Delivery Systems
  • Combined Modality Therapy
  • 10 Technology
  • 08 Information and Computing Sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Owusu, R. A., Abern, M. R., & Inman, B. A. (2013). Hyperthermia as adjunct to intravesical chemotherapy for bladder cancer. Biomed Res Int, 2013, 262313. https://doi.org/10.1155/2013/262313
Owusu, Richmond A., Michael R. Abern, and Brant A. Inman. “Hyperthermia as adjunct to intravesical chemotherapy for bladder cancer.Biomed Res Int 2013 (2013): 262313. https://doi.org/10.1155/2013/262313.
Owusu RA, Abern MR, Inman BA. Hyperthermia as adjunct to intravesical chemotherapy for bladder cancer. Biomed Res Int. 2013;2013:262313.
Owusu, Richmond A., et al. “Hyperthermia as adjunct to intravesical chemotherapy for bladder cancer.Biomed Res Int, vol. 2013, 2013, p. 262313. Pubmed, doi:10.1155/2013/262313.
Owusu RA, Abern MR, Inman BA. Hyperthermia as adjunct to intravesical chemotherapy for bladder cancer. Biomed Res Int. 2013;2013:262313.

Published In

Biomed Res Int

DOI

EISSN

2314-6141

Publication Date

2013

Volume

2013

Start / End Page

262313

Location

United States

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Urinary Bladder
  • Temperature
  • Hyperthermia, Induced
  • Humans
  • Drug Delivery Systems
  • Combined Modality Therapy
  • 10 Technology
  • 08 Information and Computing Sciences
  • 06 Biological Sciences