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Predictors of extraventricular drain-associated bacterial ventriculitis.

Publication ,  Journal Article
Williamson, RA; Phillips-Bute, BG; McDonagh, DL; Gray, MC; Zomorodi, AR; Olson, DM; Britz, GW; Laskowitz, DT; James, ML
Published in: J Crit Care
February 2014

PURPOSE: Bacterial ventriculitis (BV) may develop in patients requiring external ventricular drains (EVDs). The purpose of this study was to determine predictors of EVD-associated BV onset. MATERIALS AND METHODS: A retrospective review of Duke University Hospital patients with EVD device placement between January 2005 and May 2010 was conducted. Subject data were captured for predefined variables. Outcomes included in-hospital mortality, length of stay, and neurologic status at discharge. RESULTS: In 410 subjects with 420 EVDs, the BV rate was 10.2%. Univariate analysis indicated that age, sex, positive blood culture, duration of EVD placement, and the number of cerebrospinal fluid (CSF) samples taken were associated with BV. Of these, the number of CSF samples and sex retained significance in multivariable modeling (female: odds ratio, 0.47 [confidence interval, 0.23-0.97]; CSF samples: odds ratio, 1.08 [confidence interval 1.01-1.17]; P = .04; c index = 0.69). In this model, each CSF sample taken expanded the likelihood of BV by 8.3%. The most common pathogens were Staphylococcus or proprioniobacter (n = 26). Bacterial ventriculitis was associated with an increase in hospital length of stay (33 ± 22.9 days vs 24.6 ± 20.4 days; P = .04) but not mortality. CONCLUSION: An association exists between CSF sampling frequency and the development of EVD-associated BV. Larger prospective studies should be aimed at identifying causal relationships between these variables.

Duke Scholars

Published In

J Crit Care

DOI

EISSN

1557-8615

Publication Date

February 2014

Volume

29

Issue

1

Start / End Page

77 / 82

Location

United States

Related Subject Headings

  • Sex Factors
  • Retrospective Studies
  • Middle Aged
  • Male
  • Length of Stay
  • Humans
  • Hospitals, University
  • Female
  • Emergency & Critical Care Medicine
  • Drainage
 

Citation

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MLA
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Williamson, R. A., Phillips-Bute, B. G., McDonagh, D. L., Gray, M. C., Zomorodi, A. R., Olson, D. M., … James, M. L. (2014). Predictors of extraventricular drain-associated bacterial ventriculitis. J Crit Care, 29(1), 77–82. https://doi.org/10.1016/j.jcrc.2013.08.012
Williamson, Rachel A., Barbara G. Phillips-Bute, David L. McDonagh, Marisa C. Gray, Ali R. Zomorodi, Daiwai M. Olson, Gavin W. Britz, Daniel T. Laskowitz, and Michael L. James. “Predictors of extraventricular drain-associated bacterial ventriculitis.J Crit Care 29, no. 1 (February 2014): 77–82. https://doi.org/10.1016/j.jcrc.2013.08.012.
Williamson RA, Phillips-Bute BG, McDonagh DL, Gray MC, Zomorodi AR, Olson DM, et al. Predictors of extraventricular drain-associated bacterial ventriculitis. J Crit Care. 2014 Feb;29(1):77–82.
Williamson, Rachel A., et al. “Predictors of extraventricular drain-associated bacterial ventriculitis.J Crit Care, vol. 29, no. 1, Feb. 2014, pp. 77–82. Pubmed, doi:10.1016/j.jcrc.2013.08.012.
Williamson RA, Phillips-Bute BG, McDonagh DL, Gray MC, Zomorodi AR, Olson DM, Britz GW, Laskowitz DT, James ML. Predictors of extraventricular drain-associated bacterial ventriculitis. J Crit Care. 2014 Feb;29(1):77–82.
Journal cover image

Published In

J Crit Care

DOI

EISSN

1557-8615

Publication Date

February 2014

Volume

29

Issue

1

Start / End Page

77 / 82

Location

United States

Related Subject Headings

  • Sex Factors
  • Retrospective Studies
  • Middle Aged
  • Male
  • Length of Stay
  • Humans
  • Hospitals, University
  • Female
  • Emergency & Critical Care Medicine
  • Drainage