Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.

Journal Article (Journal Article)

In overweight/obese individuals, cardiometabolic risk factors differ by race and sex categories. Small-molecule metabolites and metabolic hormone levels might also differ across these categories and contribute to risk factor heterogeneity. To explore this possibility, we performed a cross-sectional analysis of fasting plasma levels of 69 small-molecule metabolites and 13 metabolic hormones in 500 overweight/obese adults who participated in the Weight Loss Maintenance trial. Principal-components analysis (PCA) was used for reduction of metabolite data. Race and sex-stratified comparisons of metabolite factors and metabolic hormones were performed. African Americans represented 37.4% of the study participants, and females 63.0%. Of thirteen metabolite factors identified, three differed by race and sex: levels of factor 3 (branched-chain amino acids and related metabolites, p<0.0001), factor 6 (long-chain acylcarnitines, p<0.01), and factor 2 (medium-chain dicarboxylated acylcarnitines, p<0.0001) were higher in males vs. females; factor 6 levels were higher in Caucasians vs. African Americans (p<0.0001). Significant differences were also observed in hormones regulating body weight homeostasis. Among overweight/obese adults, there are significant race and sex differences in small-molecule metabolites and metabolic hormones; these differences may contribute to risk factor heterogeneity across race and sex subgroups and should be considered in future investigations with circulating metabolites and metabolic hormones.

Full Text

Duke Authors

Cited Authors

  • Patel, MJ; Batch, BC; Svetkey, LP; Bain, JR; Turer, CB; Haynes, C; Muehlbauer, MJ; Stevens, RD; Newgard, CB; Shah, SH

Published Date

  • December 2013

Published In

Volume / Issue

  • 17 / 12

Start / End Page

  • 627 - 635

PubMed ID

  • 24117402

Pubmed Central ID

  • PMC3837434

Electronic International Standard Serial Number (EISSN)

  • 1557-8100

Digital Object Identifier (DOI)

  • 10.1089/omi.2013.0031


  • eng

Conference Location

  • United States