Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.
Journal Article (Journal Article)
In overweight/obese individuals, cardiometabolic risk factors differ by race and sex categories. Small-molecule metabolites and metabolic hormone levels might also differ across these categories and contribute to risk factor heterogeneity. To explore this possibility, we performed a cross-sectional analysis of fasting plasma levels of 69 small-molecule metabolites and 13 metabolic hormones in 500 overweight/obese adults who participated in the Weight Loss Maintenance trial. Principal-components analysis (PCA) was used for reduction of metabolite data. Race and sex-stratified comparisons of metabolite factors and metabolic hormones were performed. African Americans represented 37.4% of the study participants, and females 63.0%. Of thirteen metabolite factors identified, three differed by race and sex: levels of factor 3 (branched-chain amino acids and related metabolites, p<0.0001), factor 6 (long-chain acylcarnitines, p<0.01), and factor 2 (medium-chain dicarboxylated acylcarnitines, p<0.0001) were higher in males vs. females; factor 6 levels were higher in Caucasians vs. African Americans (p<0.0001). Significant differences were also observed in hormones regulating body weight homeostasis. Among overweight/obese adults, there are significant race and sex differences in small-molecule metabolites and metabolic hormones; these differences may contribute to risk factor heterogeneity across race and sex subgroups and should be considered in future investigations with circulating metabolites and metabolic hormones.
Full Text
Duke Authors
- Bain, James R.
- Batch, Bryan Courtney
- Newgard, Christopher Bang
- Shah, Svati Hasmukh
- Stevens, Robert David
- Svetkey, Laura Pat
Cited Authors
- Patel, MJ; Batch, BC; Svetkey, LP; Bain, JR; Turer, CB; Haynes, C; Muehlbauer, MJ; Stevens, RD; Newgard, CB; Shah, SH
Published Date
- December 2013
Published In
Volume / Issue
- 17 / 12
Start / End Page
- 627 - 635
PubMed ID
- 24117402
Pubmed Central ID
- PMC3837434
Electronic International Standard Serial Number (EISSN)
- 1557-8100
Digital Object Identifier (DOI)
- 10.1089/omi.2013.0031
Language
- eng
Conference Location
- United States