Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.
Journal Article (Journal Article;Review)
This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.
Full Text
Duke Authors
Cited Authors
- Fang, Y; Chen, X; Bajpai, M; Verma, A; Das, KM; Souza, RF; Garman, KS; Donohoe, CL; O'Farrell, NJ; Reynolds, JV; Dvorak, K
Published Date
- October 2013
Published In
Volume / Issue
- 1300 /
Start / End Page
- 187 - 199
PubMed ID
- 24117642
Electronic International Standard Serial Number (EISSN)
- 1749-6632
Digital Object Identifier (DOI)
- 10.1111/nyas.12249
Language
- eng
Conference Location
- United States