Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.

Journal Article (Journal Article;Review)

This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

Full Text

Duke Authors

Cited Authors

  • Fang, Y; Chen, X; Bajpai, M; Verma, A; Das, KM; Souza, RF; Garman, KS; Donohoe, CL; O'Farrell, NJ; Reynolds, JV; Dvorak, K

Published Date

  • October 2013

Published In

Volume / Issue

  • 1300 /

Start / End Page

  • 187 - 199

PubMed ID

  • 24117642

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Digital Object Identifier (DOI)

  • 10.1111/nyas.12249


  • eng

Conference Location

  • United States