Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma.

Journal Article (Review)

This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

Full Text

Duke Authors

Cited Authors

  • Fang, Y; Chen, X; Bajpai, M; Verma, A; Das, KM; Souza, RF; Garman, KS; Donohoe, CL; O'Farrell, NJ; Reynolds, JV; Dvorak, K

Published Date

  • October 2013

Published In

Volume / Issue

  • 1300 /

Start / End Page

  • 187 - 199

PubMed ID

  • 24117642

Electronic International Standard Serial Number (EISSN)

  • 1749-6632

Digital Object Identifier (DOI)

  • 10.1111/nyas.12249

Language

  • eng

Conference Location

  • United States