Microenvironmental regulation of cancer metastasis by miRNAs.

Journal Article (Journal Article;Review)

miRNAs are a class of small, non-coding RNAs that regulate cancer progression, especially the processes of invasion and metastasis. Although earlier studies in metastasis primarily focused on the impact that miRNAs have on the intrinsic properties of cancer cells, recent reports reveal that miRNAs also shape interactions between cancer cells and their associated stroma. In this review, we discuss current known mechanisms by which miRNAs execute their microenvironmental regulation of cancer metastasis, including regulating expression of cell membrane-bound and secreted proteins or directly transmitting mature miRNAs between different cell types. The significance of miRNA-mediated tumor-stroma interactions in regulating metastasis suggests that miRNAs may be a potential therapeutic target.

Full Text

Duke Authors

Cited Authors

  • Zhang, Y; Yang, P; Wang, X-F

Published Date

  • March 2014

Published In

Volume / Issue

  • 24 / 3

Start / End Page

  • 153 - 160

PubMed ID

  • 24125906

Pubmed Central ID

  • PMC3943699

Electronic International Standard Serial Number (EISSN)

  • 1879-3088

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2013.09.007


  • eng

Conference Location

  • England