Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.


Journal Article

The median survival of patients with idiopathic pulmonary fibrosis (IPF) continues to be approximately 3 years from the time of diagnosis, underscoring the lack of effective medical therapies for this disease. In the United States alone, approximately 40,000 patients die of this disease annually. In November 2012, the NHLBI held a workshop aimed at coordinating research efforts and accelerating the development of IPF therapies. Basic, translational, and clinical researchers gathered with representatives from the NHLBI, patient advocacy groups, pharmaceutical companies, and the U.S. Food and Drug Administration to review the current state of IPF research and identify priority areas, opportunities for collaborations, and directions for future research. The workshop was organized into groups that were tasked with assessing and making recommendations to promote progress in one of the following six critical areas of research: (1) biology of alveolar epithelial injury and aberrant repair; (2) role of extracellular matrix; (3) preclinical modeling; (4) role of inflammation and immunity; (5) genetic, epigenetic, and environmental determinants; (6) translation of discoveries into diagnostics and therapeutics. The workshop recommendations provide a basis for directing future research and strategic planning by scientific, professional, and patient communities and the NHLBI.

Full Text

Duke Authors

Cited Authors

  • Blackwell, TS; Tager, AM; Borok, Z; Moore, BB; Schwartz, DA; Anstrom, KJ; Bar-Joseph, Z; Bitterman, P; Blackburn, MR; Bradford, W; Brown, KK; Chapman, HA; Collard, HR; Cosgrove, GP; Deterding, R; Doyle, R; Flaherty, KR; Garcia, CK; Hagood, JS; Henke, CA; Herzog, E; Hogaboam, CM; Horowitz, JC; King, TE; Loyd, JE; Lawson, WE; Marsh, CB; Noble, PW; Noth, I; Sheppard, D; Olsson, J; Ortiz, LA; O'Riordan, TG; Oury, TD; Raghu, G; Roman, J; Sime, PJ; Sisson, TH; Tschumperlin, D; Violette, SM; Weaver, TE; Wells, RG; White, ES; Kaminski, N; Martinez, FJ; Wynn, TA; Thannickal, VJ; Eu, JP

Published Date

  • January 15, 2014

Published In

Volume / Issue

  • 189 / 2

Start / End Page

  • 214 - 222

PubMed ID

  • 24160862

Pubmed Central ID

  • 24160862

Electronic International Standard Serial Number (EISSN)

  • 1535-4970

Digital Object Identifier (DOI)

  • 10.1164/rccm.201306-1141WS


  • eng

Conference Location

  • United States