Electrographic seizures after convulsive status epilepticus in children and young adults: a retrospective multicenter study.

Published

Journal Article

To describe the prevalence, characteristics, and predictors of electrographic seizures after convulsive status epilepticus (CSE).This was a multicenter retrospective study in which we describe clinical and electroencephalographic (EEG) features of children (1 month to 21 years) with CSE who underwent continuous EEG monitoring.Ninety-eight children (53 males) with CSE (median age of 5 years) underwent subsequent continuous EEG monitoring after CSE. Electrographic seizures (with or without clinical correlate) were identified in 32 subjects (33%). Eleven subjects (34.4%) had electrographic-only seizures, 17 subjects (53.1%) had electroclinical seizures, and 4 subjects (12.5%) had an unknown clinical correlate. Of the 32 subjects with electrographic seizures, 15 subjects (46.9%) had electrographic status epilepticus. Factors associated with the occurrence of electrographic seizures after CSE were a previous diagnosis of epilepsy (P = .029) and the presence of interictal epileptiform discharges (P < .0005). The median (p25-p75) duration of stay in the pediatric intensive care unit was longer for children with electrographic seizures than for children without electrographic seizures (9.5 [3-22.5] vs 2 [2-5] days, Wilcoxon test, Z = 3.916, P = .0001). Four children (4.1%) died before leaving the hospital, and we could not identify a relationship between death and the presence or absence of electrographic seizures.After CSE, one-third of children who underwent EEG monitoring experienced electrographic seizures, and among these, one-third experienced entirely electrographic-only seizures. A previous diagnosis of epilepsy and the presence of interictal epileptiform discharges were risk factors for electrographic seizures.

Full Text

Cited Authors

  • Sánchez Fernández, I; Abend, NS; Arndt, DH; Carpenter, JL; Chapman, KE; Cornett, KM; Dlugos, DJ; Gallentine, WB; Giza, CC; Goldstein, JL; Hahn, CD; Lerner, JT; Matsumoto, JH; McBain, K; Nash, KB; Payne, E; Sánchez, SM; Williams, K; Loddenkemper, T

Published Date

  • February 2014

Published In

Volume / Issue

  • 164 / 2

Start / End Page

  • 339-46.e1-2 -

PubMed ID

  • 24161223

Pubmed Central ID

  • 24161223

Electronic International Standard Serial Number (EISSN)

  • 1097-6833

International Standard Serial Number (ISSN)

  • 0022-3476

Digital Object Identifier (DOI)

  • 10.1016/j.jpeds.2013.09.032

Language

  • eng