High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers.

Published online

Journal Article

The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.

Full Text

Duke Authors

Cited Authors

  • Lambotte, O; Pollara, J; Boufassa, F; Moog, C; Venet, A; Haynes, BF; Delfraissy, J-F; Saez-Cirion, A; Ferrari, G

Published Date

  • 2013

Published In

Volume / Issue

  • 8 / 9

Start / End Page

  • e74855 -

PubMed ID

  • 24086385

Pubmed Central ID

  • 24086385

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0074855

Language

  • eng

Conference Location

  • United States