High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers.
Published online
Journal Article
The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.
Full Text
Duke Authors
Cited Authors
- Lambotte, O; Pollara, J; Boufassa, F; Moog, C; Venet, A; Haynes, BF; Delfraissy, J-F; Saez-Cirion, A; Ferrari, G
Published Date
- 2013
Published In
Volume / Issue
- 8 / 9
Start / End Page
- e74855 -
PubMed ID
- 24086385
Pubmed Central ID
- 24086385
Electronic International Standard Serial Number (EISSN)
- 1932-6203
Digital Object Identifier (DOI)
- 10.1371/journal.pone.0074855
Language
- eng
Conference Location
- United States