High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers.
Publication
, Journal Article
Lambotte, O; Pollara, J; Boufassa, F; Moog, C; Venet, A; Haynes, BF; Delfraissy, J-F; Saez-Cirion, A; Ferrari, G
Published in: PLoS One
2013
The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
PLoS One
DOI
EISSN
1932-6203
Publication Date
2013
Volume
8
Issue
9
Start / End Page
e74855
Location
United States
Related Subject Headings
- Viremia
- RNA, Viral
- Multivariate Analysis
- Middle Aged
- Male
- Linear Models
- Humans
- HLA-B Antigens
- HIV-1
- HIV Long-Term Survivors
Citation
APA
Chicago
ICMJE
MLA
NLM
Lambotte, O., Pollara, J., Boufassa, F., Moog, C., Venet, A., Haynes, B. F., … Ferrari, G. (2013). High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers. PLoS One, 8(9), e74855. https://doi.org/10.1371/journal.pone.0074855
Lambotte, Olivier, Justin Pollara, Faroudy Boufassa, Christiane Moog, Alain Venet, Barton F. Haynes, Jean-François Delfraissy, Asier Saez-Cirion, and Guido Ferrari. “High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers.” PLoS One 8, no. 9 (2013): e74855. https://doi.org/10.1371/journal.pone.0074855.
Lambotte O, Pollara J, Boufassa F, Moog C, Venet A, Haynes BF, et al. High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers. PLoS One. 2013;8(9):e74855.
Lambotte, Olivier, et al. “High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers.” PLoS One, vol. 8, no. 9, 2013, p. e74855. Pubmed, doi:10.1371/journal.pone.0074855.
Lambotte O, Pollara J, Boufassa F, Moog C, Venet A, Haynes BF, Delfraissy J-F, Saez-Cirion A, Ferrari G. High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers. PLoS One. 2013;8(9):e74855.
Published In
PLoS One
DOI
EISSN
1932-6203
Publication Date
2013
Volume
8
Issue
9
Start / End Page
e74855
Location
United States
Related Subject Headings
- Viremia
- RNA, Viral
- Multivariate Analysis
- Middle Aged
- Male
- Linear Models
- Humans
- HLA-B Antigens
- HIV-1
- HIV Long-Term Survivors