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Immune activation by histones: plusses and minuses in inflammation.

Publication ,  Journal Article
Pisetsky, DS
Published in: Eur J Immunol
December 2013

Histones are highly cationic proteins that are essential components of the cell nucleus, interacting with DNA to form the nucleosome and regulating transcription. Histones, however, can transit from the cell nucleus during cell death and, once in an extracellular location, can serve as danger signals and activate immune cells. An article in this issue of the European Journal of Immunology [Eur. J. Immunol. 2013. 43: 3336-3342] reports that histones can activate monocyte-derived DCs via the NRLP3 inflammasome to induce the production of IL-1β. As such, histones, which can also stimulate TLRs, may drive events in the immunopathogenesis of a wide range of acute and chronic diseases marked by sterile inflammation. While the mechanism of this stimulation is not known, the positive charge of histones may provide a structural element to promote interaction with cells and activation of downstream signaling systems.

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Published In

Eur J Immunol

DOI

EISSN

1521-4141

Publication Date

December 2013

Volume

43

Issue

12

Start / End Page

3163 / 3166

Location

Germany

Related Subject Headings

  • Oxidative Stress
  • Neutrophils
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Inflammasomes
  • Immunology
  • Histones
  • Carrier Proteins
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Pisetsky, D. S. (2013). Immune activation by histones: plusses and minuses in inflammation. Eur J Immunol, 43(12), 3163–3166. https://doi.org/10.1002/eji.201344175
Pisetsky, David S. “Immune activation by histones: plusses and minuses in inflammation.Eur J Immunol 43, no. 12 (December 2013): 3163–66. https://doi.org/10.1002/eji.201344175.
Pisetsky DS. Immune activation by histones: plusses and minuses in inflammation. Eur J Immunol. 2013 Dec;43(12):3163–6.
Pisetsky, David S. “Immune activation by histones: plusses and minuses in inflammation.Eur J Immunol, vol. 43, no. 12, Dec. 2013, pp. 3163–66. Pubmed, doi:10.1002/eji.201344175.
Pisetsky DS. Immune activation by histones: plusses and minuses in inflammation. Eur J Immunol. 2013 Dec;43(12):3163–3166.
Journal cover image

Published In

Eur J Immunol

DOI

EISSN

1521-4141

Publication Date

December 2013

Volume

43

Issue

12

Start / End Page

3163 / 3166

Location

Germany

Related Subject Headings

  • Oxidative Stress
  • Neutrophils
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Inflammasomes
  • Immunology
  • Histones
  • Carrier Proteins
  • Animals
  • 3204 Immunology
  • 1107 Immunology