RNAi function, diversity, and loss in the fungal kingdom.

Published

Journal Article (Review)

RNAi is conserved and has been studied in a broad cross-section of the fungal kingdom, including Neurospora crassa, Schizosaccharomyces pombe, Cryptococcus neoformans, and Mucor circinelloides. And yet well known species, including the model yeast Saccharomyces cerevisiae and the plant pathogen Ustilago maydis, have lost RNAi, providing insights and opportunities to illuminate benefits conferred both by the presence of RNAi and its loss. Some of the earliest studies of RNAi were conducted in Neurospora, contemporaneously with the elucidation of RNAi in Caenorhabditis elegans. RNAi is a key epigenetic mechanism for maintaining genomic stability and integrity, as well as to defend against viruses, and given its ubiquity was likely present in the last eukaryotic common ancestor. In this review, we describe the diversity of RNAi mechanisms found in the fungi, highlighting recent work in Neurospora, S. pombe, and Cryptococcus. Finally, we consider frequent, independent losses of RNAi in diverse fungal lineages and both review and speculate on evolutionary forces that may drive the losses or result therefrom.

Full Text

Duke Authors

Cited Authors

  • Billmyre, RB; Calo, S; Feretzaki, M; Wang, X; Heitman, J

Published Date

  • December 2013

Published In

Volume / Issue

  • 21 / 6-7

Start / End Page

  • 561 - 572

PubMed ID

  • 24173579

Pubmed Central ID

  • 24173579

Electronic International Standard Serial Number (EISSN)

  • 1573-6849

Digital Object Identifier (DOI)

  • 10.1007/s10577-013-9388-2

Language

  • eng

Conference Location

  • Netherlands