Pharmacometabolomics of statin response.
Publication
, Journal Article
Krauss, RM; Zhu, H; Kaddurah-Daouk, R
Published in: Clin Pharmacol Ther
November 2013
Statins reduce risk of cardiovascular disease (CVD) by decreasing plasma low-density lipoprotein (LDL) concentrations, as well as reducing inflammation and improving endothelial function. Despite their documented efficacy, there is considerable interindividual variation in effects of statins on CVD biomarkers. In the studies summarized here, we used complementary metabolomics platforms to define global effects of a statin (simvastatin) on metabolism and to identify markers indicative of mechanisms that contribute to variation in plasma LDL response to statin treatment.
Duke Scholars
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Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
November 2013
Volume
94
Issue
5
Start / End Page
562 / 565
Location
United States
Related Subject Headings
- Sterols
- Pharmacology & Pharmacy
- Metabolomics
- Lipoproteins, LDL
- Lipids
- Lipid Metabolism
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Humans
- Gas Chromatography-Mass Spectrometry
- Chromatography, Gas
Citation
APA
Chicago
ICMJE
MLA
NLM
Krauss, R. M., Zhu, H., & Kaddurah-Daouk, R. (2013). Pharmacometabolomics of statin response. Clin Pharmacol Ther, 94(5), 562–565. https://doi.org/10.1038/clpt.2013.164
Krauss, R. M., H. Zhu, and R. Kaddurah-Daouk. “Pharmacometabolomics of statin response.” Clin Pharmacol Ther 94, no. 5 (November 2013): 562–65. https://doi.org/10.1038/clpt.2013.164.
Krauss RM, Zhu H, Kaddurah-Daouk R. Pharmacometabolomics of statin response. Clin Pharmacol Ther. 2013 Nov;94(5):562–5.
Krauss, R. M., et al. “Pharmacometabolomics of statin response.” Clin Pharmacol Ther, vol. 94, no. 5, Nov. 2013, pp. 562–65. Pubmed, doi:10.1038/clpt.2013.164.
Krauss RM, Zhu H, Kaddurah-Daouk R. Pharmacometabolomics of statin response. Clin Pharmacol Ther. 2013 Nov;94(5):562–565.
Published In
Clin Pharmacol Ther
DOI
EISSN
1532-6535
Publication Date
November 2013
Volume
94
Issue
5
Start / End Page
562 / 565
Location
United States
Related Subject Headings
- Sterols
- Pharmacology & Pharmacy
- Metabolomics
- Lipoproteins, LDL
- Lipids
- Lipid Metabolism
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Humans
- Gas Chromatography-Mass Spectrometry
- Chromatography, Gas