Pharmacometabolomics of statin response.

Journal Article (Journal Article;Review)

Statins reduce risk of cardiovascular disease (CVD) by decreasing plasma low-density lipoprotein (LDL) concentrations, as well as reducing inflammation and improving endothelial function. Despite their documented efficacy, there is considerable interindividual variation in effects of statins on CVD biomarkers. In the studies summarized here, we used complementary metabolomics platforms to define global effects of a statin (simvastatin) on metabolism and to identify markers indicative of mechanisms that contribute to variation in plasma LDL response to statin treatment.

Full Text

Duke Authors

Cited Authors

  • Krauss, RM; Zhu, H; Kaddurah-Daouk, R

Published Date

  • November 2013

Published In

Volume / Issue

  • 94 / 5

Start / End Page

  • 562 - 565

PubMed ID

  • 23945822

Pubmed Central ID

  • PMC4055080

Electronic International Standard Serial Number (EISSN)

  • 1532-6535

Digital Object Identifier (DOI)

  • 10.1038/clpt.2013.164


  • eng

Conference Location

  • United States