TRPV channels' role in osmotransduction and mechanotransduction.

Published

Journal Article (Review)

In signal transduction of metazoan cells, transient receptor potential (TRP) ion channels have been identified that respond to diverse external and internal stimuli, among them osmotic and mechanical stimuli. This chapter will summarize findings on the TRPV subfamily, both its vertebrate and invertebrate members. Of the six mammalian TRPV channels, TRPV1, -V2, and -V4 were demonstrated to function in transduction of osmotic and/or mechanical stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis in vertebrates. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic stimuli in C. elegans. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue mechanosensory and osmosensory deficits of the TRPV mutant line osm-9 in C. elegans, despite no more than 26% orthology of the respective amino acid sequences.

Full Text

Duke Authors

Cited Authors

  • Liedtke, W

Published Date

  • 2007

Published In

Start / End Page

  • 473 - 487

PubMed ID

  • 17217074

Pubmed Central ID

  • 17217074

International Standard Serial Number (ISSN)

  • 0171-2004

Digital Object Identifier (DOI)

  • 10.1007/978-3-540-34891-7_28

Language

  • eng

Conference Location

  • Germany