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In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI.

Publication ,  Journal Article
Branca, RT; Zhang, L; Warren, WS; Auerbach, E; Khanna, A; Degan, S; Ugurbil, K; Maronpot, R
Published in: PloS one
January 2013

The recent discovery of active Brown Adipose Tissue (BAT) in adult humans has opened new avenues for obesity research and treatment, as reduced BAT activity seem to be implicated in human energy imbalance, diabetes, and hypertension. However, clinical applications are currently limited by the lack of non-invasive tools for measuring mass and function of this tissue in humans. Here we present a new magnetic resonance imaging method based on the normally invisible intermolecular multiple-quantum coherence (1)H MR signal. This method, which doesn't require special hardware modifications, can be used to overcome partial volume effect, the major limitation of MR-based approaches that are currently being investigated for the detection of BAT in humans. With this method we can exploit the characteristic cellular structure of BAT to selectively image it, even when (as in humans) it is intimately mixed with other tissues. We demonstrate and validate this method in mice using PET scans and histology. We compare this methodology with conventional (1)H MR fat fraction methods. Finally, we investigate its feasibility for the detection of BAT in humans.

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Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

January 2013

Volume

8

Issue

9

Start / End Page

e74206

Related Subject Headings

  • Radiography
  • Quantum Theory
  • Positron-Emission Tomography
  • Phantoms, Imaging
  • Middle Aged
  • Mice, Nude
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Male
 

Citation

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Branca, R. T., Zhang, L., Warren, W. S., Auerbach, E., Khanna, A., Degan, S., … Maronpot, R. (2013). In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI. PloS One, 8(9), e74206. https://doi.org/10.1371/journal.pone.0074206
Branca, Rosa T., Le Zhang, Warren S. Warren, Edward Auerbach, Arjun Khanna, Simone Degan, Kamil Ugurbil, and Robert Maronpot. “In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI.PloS One 8, no. 9 (January 2013): e74206. https://doi.org/10.1371/journal.pone.0074206.
Branca RT, Zhang L, Warren WS, Auerbach E, Khanna A, Degan S, et al. In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI. PloS one. 2013 Jan;8(9):e74206.
Branca, Rosa T., et al. “In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI.PloS One, vol. 8, no. 9, Jan. 2013, p. e74206. Epmc, doi:10.1371/journal.pone.0074206.
Branca RT, Zhang L, Warren WS, Auerbach E, Khanna A, Degan S, Ugurbil K, Maronpot R. In vivo noninvasive detection of Brown Adipose Tissue through intermolecular zero-quantum MRI. PloS one. 2013 Jan;8(9):e74206.

Published In

PloS one

DOI

EISSN

1932-6203

ISSN

1932-6203

Publication Date

January 2013

Volume

8

Issue

9

Start / End Page

e74206

Related Subject Headings

  • Radiography
  • Quantum Theory
  • Positron-Emission Tomography
  • Phantoms, Imaging
  • Middle Aged
  • Mice, Nude
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Male