Transplantation of CD34+ hematopoietic progenitor cells.

Journal Article (Clinical Trial;Journal Article)

Sixty-six stage IV breast cancer patients received high dose chemotherapy followed by autologous transplantation of CD34-positive(+) cells obtained from the bone marrow and/or granulocyte colony stimulating factor (G-CSF)-mobilized peripheral blood. Grafts were examined for the presence of tumor using conventional histology and immunocytochemical staining. Patients achieved a granulocyte count of 500 x 10(9)/liter 10-12 days posttransplant, with a platelet count of > 20 x 10(9)/liter in 14-15 days. Enrichment of CD34+ cells from the peripheral blood progenitor cell (PBPC) collections resulted in a 1.3 to 4.0 log depletion of breast cancer cells from the graft.

Full Text

Duke Authors

Cited Authors

  • Shpall, EJ; Jones, RB; Bearman, SI; Purdy, MH; Franklin, WA; Heimfeld, S; Berenson, RJ

Published Date

  • 1994

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 145 - 147

PubMed ID

  • 7522899

Pubmed Central ID

  • 7522899

International Standard Serial Number (ISSN)

  • 1061-6128

Digital Object Identifier (DOI)

  • 10.1089/scd.1.1994.3.145


  • eng

Conference Location

  • United States