Salicylic acid activates DNA damage responses to potentiate plant immunity.

Journal Article (Journal Article)

DNA damage is normally detrimental to living organisms. Here we show that it can also serve as a signal to promote immune responses in plants. We found that the plant immune hormone salicylic acid (SA) can trigger DNA damage in the absence of a genotoxic agent. The DNA damage sensor proteins RAD17 and ATR are required for effective immune responses. These sensor proteins are negatively regulated by a key immune regulator, SNI1 (suppressor of npr1-1, inducible 1), which we found is a subunit of the structural maintenance of chromosome (SMC) 5/6 complex required for controlling DNA damage. Elevated DNA damage caused by the sni1 mutation or treatment with a DNA-damaging agent markedly enhances SA-mediated defense gene expression. Our study suggests that activation of DNA damage responses is an intrinsic component of the plant immune responses.

Full Text

Duke Authors

Cited Authors

  • Yan, S; Wang, W; Marqués, J; Mohan, R; Saleh, A; Durrant, WE; Song, J; Dong, X

Published Date

  • November 2013

Published In

Volume / Issue

  • 52 / 4

Start / End Page

  • 602 - 610

PubMed ID

  • 24207055

Pubmed Central ID

  • PMC3863363

Electronic International Standard Serial Number (EISSN)

  • 1097-4164

International Standard Serial Number (ISSN)

  • 1097-2765

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2013.09.019

Language

  • eng