Salicylic acid activates DNA damage responses to potentiate plant immunity.

Published

Journal Article

DNA damage is normally detrimental to living organisms. Here we show that it can also serve as a signal to promote immune responses in plants. We found that the plant immune hormone salicylic acid (SA) can trigger DNA damage in the absence of a genotoxic agent. The DNA damage sensor proteins RAD17 and ATR are required for effective immune responses. These sensor proteins are negatively regulated by a key immune regulator, SNI1 (suppressor of npr1-1, inducible 1), which we found is a subunit of the structural maintenance of chromosome (SMC) 5/6 complex required for controlling DNA damage. Elevated DNA damage caused by the sni1 mutation or treatment with a DNA-damaging agent markedly enhances SA-mediated defense gene expression. Our study suggests that activation of DNA damage responses is an intrinsic component of the plant immune responses.

Full Text

Duke Authors

Cited Authors

  • Yan, S; Wang, W; Marqués, J; Mohan, R; Saleh, A; Durrant, WE; Song, J; Dong, X

Published Date

  • November 2013

Published In

Volume / Issue

  • 52 / 4

Start / End Page

  • 602 - 610

PubMed ID

  • 24207055

Pubmed Central ID

  • 24207055

Electronic International Standard Serial Number (EISSN)

  • 1097-4164

International Standard Serial Number (ISSN)

  • 1097-2765

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2013.09.019

Language

  • eng