Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy.


Journal Article

Multimodal imaging offers the potential to improve diagnosis and enhance the specificity of photothermal cancer therapy. Toward this goal, gadolinium-conjugated gold nanoshells are engineered and it is demonstrated that they enhance contrast for magnetic resonance imaging, X-ray, optical coherence tomography, reflectance confocal microscopy, and two-photon luminescence. Additionally, these particles effectively convert near-infrared light to heat, which can be used to ablate cancer cells. Ultimately, these studies demonstrate the potential of gadolinium-nanoshells for image-guided photothermal ablation.

Full Text

Duke Authors

Cited Authors

  • Coughlin, AJ; Ananta, JS; Deng, N; Larina, IV; Decuzzi, P; West, JL

Published Date

  • February 2014

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • 556 - 565

PubMed ID

  • 24115690

Pubmed Central ID

  • 24115690

Electronic International Standard Serial Number (EISSN)

  • 1613-6829

International Standard Serial Number (ISSN)

  • 1613-6810

Digital Object Identifier (DOI)

  • 10.1002/smll.201302217


  • eng