The role of cognitive functioning in medication adherence of children and adolescents with HIV infection.

Journal Article (Journal Article)

OBJECTIVE: To evaluate the relationship between cognitive functioning and medication adherence in children and adolescents with perinatally acquired HIV infection. METHODS: Children and adolescents, ages 3-18 (N = 1,429), received a cognitive evaluation and adherence assessment. Multiple logistic regression models were used to identify associations between adherence and cognitive status, adjusting for potential confounding factors. RESULTS: Children's average cognitive performance was within the low-average range; 16% of children were cognitively impaired (MDI/FSIQ <70). Cognitive status was not associated with adherence to full medication regimens; however, children with borderline/low average cognitive functioning (IQ 70-84) had increased odds of nonadherence to the protease inhibitor class of antiretroviral therapy. Recent stressful life events and child health characteristics, such as HIV RNA detectability, were significantly associated with nonadherence. CONCLUSION: Cognitive status plays a limited role in medication adherence. Child and caregiver psychosocial and health characteristics should inform interventions to support adherence.

Full Text

Duke Authors

Cited Authors

  • Malee, K; Williams, PL; Montepiedra, G; Nichols, S; Sirois, PA; Storm, D; Farley, J; Kammerer, B; PACTG 219C Team,

Published Date

  • March 2009

Published In

Volume / Issue

  • 34 / 2

Start / End Page

  • 164 - 175

PubMed ID

  • 18647794

Pubmed Central ID

  • PMC2722123

Electronic International Standard Serial Number (EISSN)

  • 1465-735X

Digital Object Identifier (DOI)

  • 10.1093/jpepsy/jsn068


  • eng

Conference Location

  • United States