Pinhole SPECT for Imaging In-111 in the Head


Journal Article

With the development of targeted radiotherapy techniques, quantitation of radionuclides that emit high-energy photons (>140 keV) by gamma camera scintigraphy has become increasingly important in external imaging applications. The radionuclide In-111 (171 and 245 keV) has been used experimentally with monoclonal antibodies and receptor specific pharmaceuticals to obtain pre-treatment information for various types of brain tumors. Conventional protocols for imaging In-111 utilize parallel-hole collimators designed for medium energy (ME) applications. The performance of ME collimators suffers from decreased spatial resolution and/or sensitivity. Septal penetration can also lead to image degradation. Pinhole collimation can offer improved spatial resolution and/or sensitivity compared with ME collimators when imaging In-111 in objects the size of the head or smaller, especially when restricting the field-of-view to regions near the central plane. Simulation and experimental phantom studies have been used to investigate pinhole SPECT for imaging In-111 in the head. Chang attenuation and dual-window scatter subtraction compensation methods have been evaluated for potential accuracy in pinhole geometry. Results have shown improved image quality with pinhole collimation with a ≤15% quantitative accuracy in phantom studies. We demonstrate that pinhole SPECT is a viable alternative to ME collimator imaging of In-111 in objects the size of the head. © 1995 IEEE.

Full Text

Duke Authors

Cited Authors

  • Johnson, EL; Jaszczak, RJ; Wang, H; Li, J; Greer, KL; Coleman, RE

Published Date

  • January 1, 1995

Published In

Volume / Issue

  • 42 / 4

Start / End Page

  • 1126 - 1132

Electronic International Standard Serial Number (EISSN)

  • 1558-1578

International Standard Serial Number (ISSN)

  • 0018-9499

Digital Object Identifier (DOI)

  • 10.1109/23.467737

Citation Source

  • Scopus