An iron tetrahydroporphyrin prosthetic group common to both assimilatory and dissimilatory sulfite reductases

Journal Article

The heme † † The terms "heme" and "porphin" are used as defined in Ref. 1 and 6. chromophore of the "assimilatory" E. coli sulfite reductase is an iron-octacarboxylic tetrahydroporphyrin of the isobacteriochlorin type (1). Although the two "dissimilatory" sulfite reductases, desulfoviridin and desulforubidin, from the sulfate reducing bacteria Desulfovibrio gigas and Desulfovibrio desulfuricans (Norway strain), have absorption spectra and reaction products which differ from those of E. coli sulfite reductase, the present studies indicate that they contain prosthetic groups with an organic structure closely similar or identical to that of the E. coli sulfite reductase heme. EPR spectra show high-spin ferriheme in all three enzymes. It is clear, however, that the prosthetic groups must reside in substantially different environments within their respective proteins. © 1973.

Full Text

Duke Authors

Cited Authors

  • Murphy, MJ; Siegel, LM; Kamin, H; DerVartanian, DV; Lee, JP; LeGall, J; Peck, HD

Published Date

  • September 5, 1973

Published In

Volume / Issue

  • 54 / 1

Start / End Page

  • 82 - 88

PubMed ID

  • 4354952

Electronic International Standard Serial Number (EISSN)

  • 1090-2104

International Standard Serial Number (ISSN)

  • 0006-291X

Digital Object Identifier (DOI)

  • 10.1016/0006-291X(73)90891-7

Citation Source

  • Scopus