Time course for development of vagal inhibition of the heart in neonatal rats

Published

Journal Article

Heart rate was recorded in anesthetized rats 1, 3 and 7 days after birth, and the cut peripheral end of the right vagus nerve stimulated electrically at frequencies of 5, 10, 20 and 40 Hz. Control heart rate increased from 344 ± 8 beats/min on eay one to 490 ± 10 beats/min on day seven. Stimulation 6-24 hours after birth slowed the heart rate. At 3 days, slowing was more marked at all frequencies and greatly enhanced at 20 and 40 Hz. It is concluded that efferent cardiac vagal fibers conduct action potentials and that ganglionic and post-ganglionic neurotransmission is established in rats within 6 hours after birth. © 1978.

Full Text

Duke Authors

Cited Authors

  • Mills, E

Published Date

  • 1978-12-31

Published In

Volume / Issue

  • 23 / 27-28

Start / End Page

  • 2717 - 2720

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(78)90651-3

Citation Source

  • Scopus