Siroheme: a new prosthetic group participating in six-electron reduction reactions catalyzed by both sulfite and nitrite reductases.
Journal Article (Journal Article)
Ferredoxin-nitrite reductase (EC 1.7.7.1) of spinach, an enzyme that catalyzes the six-electron reduction of nitrite to ammonia, contains siroheme, the new type of prosthetic group recently found in several sulfite reductases (both assimilatory and dissimilatory) that can catalyze the reduction of sulfite to sulfide, also a six-electron reduction. The prosthetic group of sulfite reductase had previously been shown to be an iron-tetrahydroporphyrin of the isobacteriochlorin type (adjacent pyrrole rings reduced) with eight carboxylate side chains. This finding suggests that both types of "multi-electron" reduction processes may share common mechanistic features.
Full Text
Duke Authors
Cited Authors
- Murphy, MJ; Siegel, LM; Tove, SR; Kamin, H
Published Date
- March 1, 1974
Published In
Volume / Issue
- 71 / 3
Start / End Page
- 612 - 616
PubMed ID
- 4595566
Pubmed Central ID
- PMC388061
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.71.3.612
Language
- eng
Conference Location
- United States