Therapy of Hepatic Failure
There has been tremendous improvement in the past concerning the prevention of liver failure after liver resections. Still this can not be achieved in all cases. Treatment options are still quite limited, Besides classical conservative treatment, liver assist devices are being investigated. Mainly three different approaches can be distinguished. First, a physical system, similar to dialysis, but with the addition of albumin, enabling clearance of albumin bound compounds. Second, a system using isolated hepatocytes, which shall lead to detoxification and ideally to some extend of liver synthesis. Finally, extracorporeal perfusion of whole livers is carried out, which potentially has the advantage of producing bile and thereby clearing toxic substances. As the liver has great potential to regenerate such systems would probably only be required for a limited time period.
Schön, MR; Tillmann, HL; Hauss, J
Volume / Issue
Start / End Page
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)