SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects.

Published

Journal Article

Essential tremor (ET) is characterized by postural and action tremor.(1-3) A genome-wide association study (GWAS) identified a LINGO1 gene variant to be associated with ET.(4) Subsequent GWAS further identified an intronic variant (rs3794087) of the main glial glutamate transporter (SLC1A2) gene to be associated with ET with an odds ratio (OR) of approximately 1.4.(5) We conducted a case-control study to examine the SLC1A2 gene variant in an Asian cohort of ET. In addition, we also investigated the variant in patients with Parkinson disease (PD) because the GWAS LINGO1 variant has been implicated in both ET and PD and etiologic links between the conditions have been suggested.(6.)

Full Text

Duke Authors

Cited Authors

  • Tan, E-K; Foo, J-N; Tan, L; Au, W-L; Prakash, KM; Ng, E; Ikram, MK; Wong, T-Y; Liu, J-J; Zhao, Y

Published Date

  • April 23, 2013

Published In

Volume / Issue

  • 80 / 17

Start / End Page

  • 1618 - 1619

PubMed ID

  • 23596072

Pubmed Central ID

  • 23596072

Electronic International Standard Serial Number (EISSN)

  • 1526-632X

Digital Object Identifier (DOI)

  • 10.1212/WNL.0b013e31828f1903

Language

  • eng

Conference Location

  • United States