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SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects.

Publication ,  Journal Article
Tan, E-K; Foo, J-N; Tan, L; Au, W-L; Prakash, KM; Ng, E; Ikram, MK; Wong, T-Y; Liu, J-J; Zhao, Y
Published in: Neurology
April 23, 2013

Essential tremor (ET) is characterized by postural and action tremor.(1-3) A genome-wide association study (GWAS) identified a LINGO1 gene variant to be associated with ET.(4) Subsequent GWAS further identified an intronic variant (rs3794087) of the main glial glutamate transporter (SLC1A2) gene to be associated with ET with an odds ratio (OR) of approximately 1.4.(5) We conducted a case-control study to examine the SLC1A2 gene variant in an Asian cohort of ET. In addition, we also investigated the variant in patients with Parkinson disease (PD) because the GWAS LINGO1 variant has been implicated in both ET and PD and etiologic links between the conditions have been suggested.(6.)

Duke Scholars

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

April 23, 2013

Volume

80

Issue

17

Start / End Page

1618 / 1619

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Glutamate Plasma Membrane Transport Proteins
  • Genome-Wide Association Study
  • Female
  • Excitatory Amino Acid Transporter 2
 

Citation

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MLA
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Tan, E.-K., Foo, J.-N., Tan, L., Au, W.-L., Prakash, K. M., Ng, E., … Zhao, Y. (2013). SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects. Neurology, 80(17), 1618–1619. https://doi.org/10.1212/WNL.0b013e31828f1903
Tan, Eng-King, Jia-Nee Foo, Louis Tan, Wing-Lok Au, Kumar M. Prakash, Ebonne Ng, M Kamran Ikram, Tien-Yin Wong, Jian-Jun Liu, and Yi Zhao. “SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects.Neurology 80, no. 17 (April 23, 2013): 1618–19. https://doi.org/10.1212/WNL.0b013e31828f1903.
Tan E-K, Foo J-N, Tan L, Au W-L, Prakash KM, Ng E, et al. SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects. Neurology. 2013 Apr 23;80(17):1618–9.
Tan, Eng-King, et al. “SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects.Neurology, vol. 80, no. 17, Apr. 2013, pp. 1618–19. Pubmed, doi:10.1212/WNL.0b013e31828f1903.
Tan E-K, Foo J-N, Tan L, Au W-L, Prakash KM, Ng E, Ikram MK, Wong T-Y, Liu J-J, Zhao Y. SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects. Neurology. 2013 Apr 23;80(17):1618–1619.

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

April 23, 2013

Volume

80

Issue

17

Start / End Page

1618 / 1619

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Humans
  • Glutamate Plasma Membrane Transport Proteins
  • Genome-Wide Association Study
  • Female
  • Excitatory Amino Acid Transporter 2