Pharmacology of antiplatelet agents.

Published

Journal Article (Review)

Pharmacotherapies with agents that inhibit platelet function have proven to be effective in the treatment of acute coronary syndromes, and in the prevention of complications during and after percutaneous coronary intervention. Because of multiple synergetic pathways of platelet activation and their close interplay with coagulation, current treatment strategies are based not only on platelet inhibition, but also on the attenuation of procoagulant activity, inhibition of thrombin generation, and enhancement of clot dissolution. Current strategies can be broadly categorized as anticoagulants, antiplatelet agents, and fibrinolytics. This review focuses on the pharmacology of current antiplatelet therapy primarily targeting the inhibition of the enzyme cyclooxygenase 1, the P2Y12 receptor, the glycoprotein IIb/IIIa receptor, and protease-activated receptor 1.

Full Text

Duke Authors

Cited Authors

  • Kalra, K; Franzese, CJ; Gesheff, MG; Lev, EI; Pandya, S; Bliden, KP; Tantry, US; Gurbel, PA

Published Date

  • December 2013

Published In

Volume / Issue

  • 15 / 12

Start / End Page

  • 371 -

PubMed ID

  • 24142550

Pubmed Central ID

  • 24142550

Electronic International Standard Serial Number (EISSN)

  • 1534-6242

Digital Object Identifier (DOI)

  • 10.1007/s11883-013-0371-3

Language

  • eng

Conference Location

  • United States