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Mechanical properties and compositions of tissue engineered and native arteries.

Publication ,  Journal Article
Dahl, SLM; Rhim, C; Song, YC; Niklason, LE
Published in: Ann Biomed Eng
March 2007

With the goal of mimicking the mechanical properties of a given native tissue, tissue engineers seek to culture replacement tissues with compositions similar to those of native tissues. In this report, differences between the mechanical properties of engineered arteries and native arteries were correlated with differences in tissue composition. Engineered arteries failed to match the strengths or compliances of native tissues. Lower strengths of engineered arteries resulted partially from inferior organization of collagen, but not from differences in collagen density. Furthermore, ultimate strengths of engineered vessels were significantly reduced by the presence of residual polyglycolic acid polymer fragments, which caused stress concentrations in the vessel wall. Lower compliances of engineered vessels resulted from minimal smooth muscle cell contractility and a lack of organized extracellular elastin. Organization of elastin and collagen in engineered arteries may have been partially hindered by high concentrations of sulfated glycosaminoglycans. Tissue engineers should continue to regulate cell phenotype and promote synthesis of proteins that are known to dominate the mechanical properties of the associated native tissue. However, we should also be aware of the potential negative impacts of polymer fragments and glycosaminoglycans on the mechanical properties of engineered tissues.

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Published In

Ann Biomed Eng

DOI

ISSN

0090-6964

Publication Date

March 2007

Volume

35

Issue

3

Start / End Page

348 / 355

Location

United States

Related Subject Headings

  • Tissue Engineering
  • Swine
  • Polyglycolic Acid
  • Biomedical Engineering
  • Arteries
  • Animals
  • 4003 Biomedical engineering
  • 11 Medical and Health Sciences
  • 09 Engineering
 

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Dahl, S. L. M., Rhim, C., Song, Y. C., & Niklason, L. E. (2007). Mechanical properties and compositions of tissue engineered and native arteries. Ann Biomed Eng, 35(3), 348–355. https://doi.org/10.1007/s10439-006-9226-1
Dahl, Shannon L. M., Caroline Rhim, Ying C. Song, and Laura E. Niklason. “Mechanical properties and compositions of tissue engineered and native arteries.Ann Biomed Eng 35, no. 3 (March 2007): 348–55. https://doi.org/10.1007/s10439-006-9226-1.
Dahl SLM, Rhim C, Song YC, Niklason LE. Mechanical properties and compositions of tissue engineered and native arteries. Ann Biomed Eng. 2007 Mar;35(3):348–55.
Dahl, Shannon L. M., et al. “Mechanical properties and compositions of tissue engineered and native arteries.Ann Biomed Eng, vol. 35, no. 3, Mar. 2007, pp. 348–55. Pubmed, doi:10.1007/s10439-006-9226-1.
Dahl SLM, Rhim C, Song YC, Niklason LE. Mechanical properties and compositions of tissue engineered and native arteries. Ann Biomed Eng. 2007 Mar;35(3):348–355.
Journal cover image

Published In

Ann Biomed Eng

DOI

ISSN

0090-6964

Publication Date

March 2007

Volume

35

Issue

3

Start / End Page

348 / 355

Location

United States

Related Subject Headings

  • Tissue Engineering
  • Swine
  • Polyglycolic Acid
  • Biomedical Engineering
  • Arteries
  • Animals
  • 4003 Biomedical engineering
  • 11 Medical and Health Sciences
  • 09 Engineering