The effects of femoral graft placement on cartilage thickness after anterior cruciate ligament reconstruction.

Journal Article (Journal Article)

Altered joint motion has been thought to be a contributing factor in the long-term development of osteoarthritis after ACL reconstruction. While many studies have quantified knee kinematics after ACL injury and reconstruction, there is limited in vivo data characterizing the effects of altered knee motion on cartilage thickness distributions. Thus, the objective of this study was to compare cartilage thickness distributions in two groups of patients with ACL reconstruction: one group in which subjects received a non-anatomic reconstruction that resulted in abnormal joint motion and another group in which subjects received an anatomically placed graft that more closely restored normal knee motion. Ten patients with anatomic graft placement (mean follow-up: 20 months) and 12 patients with non-anatomic graft placement (mean follow-up: 18 months) were scanned using high-resolution MR imaging. These images were used to generate 3D mesh models of both knees of each patient. The operative and contralateral knee models were registered to each other and a grid sampling system was used to make site-specific comparisons of cartilage thickness. Patients in the non-anatomic graft placement group demonstrated a significant decrease in cartilage thickness along the medial intercondylar notch in the operative knee relative to the intact knee (8%). In the anatomic graft placement group, no significant changes were observed. These findings suggest that restoring normal knee motion after ACL injury may help to slow the progression of degeneration. Therefore, graft placement may have important implications on the development of osteoarthritis after ACL reconstruction.

Full Text

Duke Authors

Cited Authors

  • Okafor, EC; Utturkar, GM; Widmyer, MR; Abebe, ES; Collins, AT; Taylor, DC; Spritzer, CE; Moorman, CT; Garrett, WE; DeFrate, LE

Published Date

  • January 3, 2014

Published In

Volume / Issue

  • 47 / 1

Start / End Page

  • 96 - 101

PubMed ID

  • 24210473

Pubmed Central ID

  • PMC3874409

Electronic International Standard Serial Number (EISSN)

  • 1873-2380

Digital Object Identifier (DOI)

  • 10.1016/j.jbiomech.2013.10.003


  • eng

Conference Location

  • United States