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Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value.

Publication ,  Journal Article
Heye, T; Boll, DT; Reiner, CS; Bashir, MR; Dale, BM; Merkle, EM
Published in: J Magn Reson Imaging
May 2014

PURPOSE: To investigate variation in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameter measurements between different methods of precontrast tissue relaxation (T10) estimation: pixel-based mapping versus a fixed reference value. MATERIALS AND METHODS: In 15 DCE-MRI studies the female pelvis, uterine fibroids, the left psoas muscle, and the fifth lumbar vertebral body were chosen to represent tissues with varying perfusion characteristics. All DCEMRI studies were processed using a variable flip angle T10 map and a fixed T10 reference value of 1000 msec. A subset of five DCE-MRI studies were each processed multiple times using the fixed T10 method with the reference T10 ranging from 0–2000 msec in 100-msec increments. Pharmacokinetic measurements of Ktrans, kep, ve, and initial area under the gadolinium curve (iAUGC) were performed maintaining the identical position for region of interest placement on each structure. RESULTS: The mean difference in pharmacokinetic output between the pixel-based T10 map and the fixed T10 reference value ranged from 6.6% for kep in the muscle to 54.9% for iAUGC in the vertebral body. At lower T10 (<1000 msec) aberrations in T10 estimation resulted in a larger error. Accurate measurement of T10 for each structure subsequently incorporated as a fixed T10 reference value yielded relative differences from 41.8% to 22.3% compared to the pixel-based T10 map. CONCLUSION: Direct comparison of pharmacokinetic parameters derived from a pixel-based approach versus a reference value uniformly applied to all pixels for T10 estimation is impeded by the inherent spatial heterogeneity of T10 within tissues.

Duke Scholars

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

May 2014

Volume

39

Issue

5

Start / End Page

1136 / 1145

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Reference Values
  • Pelvis
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Models, Biological
  • Middle Aged
  • Metabolic Clearance Rate
 

Citation

APA
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ICMJE
MLA
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Heye, T., Boll, D. T., Reiner, C. S., Bashir, M. R., Dale, B. M., & Merkle, E. M. (2014). Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value. J Magn Reson Imaging, 39(5), 1136–1145. https://doi.org/10.1002/jmri.24262
Heye, Tobias, Daniel T. Boll, Caecilia S. Reiner, Mustafa R. Bashir, Brian M. Dale, and Elmar M. Merkle. “Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value.J Magn Reson Imaging 39, no. 5 (May 2014): 1136–45. https://doi.org/10.1002/jmri.24262.
Heye T, Boll DT, Reiner CS, Bashir MR, Dale BM, Merkle EM. Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value. J Magn Reson Imaging. 2014 May;39(5):1136–45.
Heye, Tobias, et al. “Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value.J Magn Reson Imaging, vol. 39, no. 5, May 2014, pp. 1136–45. Pubmed, doi:10.1002/jmri.24262.
Heye T, Boll DT, Reiner CS, Bashir MR, Dale BM, Merkle EM. Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value. J Magn Reson Imaging. 2014 May;39(5):1136–1145.
Journal cover image

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

May 2014

Volume

39

Issue

5

Start / End Page

1136 / 1145

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Reference Values
  • Pelvis
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Models, Biological
  • Middle Aged
  • Metabolic Clearance Rate