Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1.
Publication
, Journal Article
Pullarkat, ST; Pullarkat, V; Lagoo, A; Brynes, R; Weiss, LM; Bedell, V; Chen, W; Huang, Q; Gaal, K; Weisenburger, DD; Kim, YS
Published in: Leuk Res
November 2013
Mast cells are often increased in AML with t(8;21). We analyzed characteristics of mast cells to elucidate their relationship with leukemic blasts. In 31 cases in which the results of KIT mutation analysis were available, five cases showed mutations. None of the cases positive for KIT mutation showed increased mast cells. In five cases with increased mast cells in which targeted-FISH analysis was performed for RUNX1-RUNX1T1, fusion signals demonstrated the translocation in mast cells in all cases. These findings confirm the shared origin between mast cells and leukemic blasts in AML with t(8;21).
Duke Scholars
Published In
Leuk Res
DOI
EISSN
1873-5835
Publication Date
November 2013
Volume
37
Issue
11
Start / End Page
1572 / 1575
Location
England
Related Subject Headings
- Tumor Cells, Cultured
- Translocation, Genetic
- RUNX1 Translocation Partner 1 Protein
- Proto-Oncogene Proteins c-kit
- Oncogene Proteins, Fusion
- Mutation
- Mast Cells
- Leukemia, Myeloid, Acute
- In Situ Hybridization, Fluorescence
- Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Pullarkat, S. T., Pullarkat, V., Lagoo, A., Brynes, R., Weiss, L. M., Bedell, V., … Kim, Y. S. (2013). Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. Leuk Res, 37(11), 1572–1575. https://doi.org/10.1016/j.leukres.2013.08.010
Pullarkat, Sheeja T., Vinod Pullarkat, Anand Lagoo, Russell Brynes, Lawrence M. Weiss, Victoria Bedell, Wengang Chen, et al. “Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1.” Leuk Res 37, no. 11 (November 2013): 1572–75. https://doi.org/10.1016/j.leukres.2013.08.010.
Pullarkat ST, Pullarkat V, Lagoo A, Brynes R, Weiss LM, Bedell V, et al. Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. Leuk Res. 2013 Nov;37(11):1572–5.
Pullarkat, Sheeja T., et al. “Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1.” Leuk Res, vol. 37, no. 11, Nov. 2013, pp. 1572–75. Pubmed, doi:10.1016/j.leukres.2013.08.010.
Pullarkat ST, Pullarkat V, Lagoo A, Brynes R, Weiss LM, Bedell V, Chen W, Huang Q, Gaal K, Weisenburger DD, Kim YS. Characterization of bone marrow mast cells in acute myeloid leukemia with t(8;21) (q22;q22); RUNX1-RUNX1T1. Leuk Res. 2013 Nov;37(11):1572–1575.
Published In
Leuk Res
DOI
EISSN
1873-5835
Publication Date
November 2013
Volume
37
Issue
11
Start / End Page
1572 / 1575
Location
England
Related Subject Headings
- Tumor Cells, Cultured
- Translocation, Genetic
- RUNX1 Translocation Partner 1 Protein
- Proto-Oncogene Proteins c-kit
- Oncogene Proteins, Fusion
- Mutation
- Mast Cells
- Leukemia, Myeloid, Acute
- In Situ Hybridization, Fluorescence
- Immunology