Transcription and ncRNAs: at the cent(rome)re of kinetochore assembly and maintenance.


Journal Article (Review)

Centromeres are sites of chromosomal spindle attachment during mitosis and meiosis. Centromeres are defined, in part, by a distinct chromatin landscape in which histone H3 is replaced by the conserved histone H3 variant, CENP-A. Sequences competent for centromere formation and function vary among organisms and are typically composed of repetitive DNA. It is unclear how such diverse genomic signals are integrated with the epigenetic mechanisms that govern CENP-A incorporation at a single locus on each chromosome. Recent work highlights the intriguing possibility that the transcriptional properties of centromeric core DNA contribute to centromere identity and maintenance through cell division. Moreover, core-derived noncoding RNAs (ncRNAs) have emerged as active participants in the regulation and control of centromere activity in plants and mammals. This paper reviews the transcriptional properties of eukaryotic centromeres and discusses the known roles of core-derived ncRNAs in chromatin integrity, kinetochore assembly, and centromere activity.

Full Text

Duke Authors

Cited Authors

  • Scott, KC

Published Date

  • December 2013

Published In

Volume / Issue

  • 21 / 6-7

Start / End Page

  • 643 - 651

PubMed ID

  • 24190519

Pubmed Central ID

  • 24190519

Electronic International Standard Serial Number (EISSN)

  • 1573-6849

Digital Object Identifier (DOI)

  • 10.1007/s10577-013-9387-3


  • eng

Conference Location

  • Netherlands