Determining γδ versus αß T cell development.

Journal Article (Journal Article;Review)

The thymus produces several types of functionally distinct T cell subsets. However, at a more fundamental level only two genetically distinct T cell lineages exist: the γδ and αß T cell lineages. Precisely how these two T cell lineages are generated from common thymocyte progenitor cells remains to be fully elucidated and is under intense investigation. Here, we highlight recent findings that have helped to provide important clues to the mechanisms that underpin the generation of γδ T cells in the mouse thymus.

Full Text

Duke Authors

Cited Authors

  • Ciofani, M; Zúñiga-Pflücker, JC

Published Date

  • September 2010

Published In

Volume / Issue

  • 10 / 9

Start / End Page

  • 657 - 663

PubMed ID

  • 20725107

Electronic International Standard Serial Number (EISSN)

  • 1474-1741

Digital Object Identifier (DOI)

  • 10.1038/nri2820


  • eng

Conference Location

  • England