A common biological basis of obesity and nicotine addiction.

Journal Article (Journal Article)

Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34,216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10(-7)). These findings replicate in a second large data set (N=127,274, thereof 76,242 smokers) for both SI (P=1.2 × 10(-5)) and CPD (P=9.3 × 10(-5)). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity.

Full Text

Duke Authors

Cited Authors

  • Thorgeirsson, TE; Gudbjartsson, DF; Sulem, P; Besenbacher, S; Styrkarsdottir, U; Thorleifsson, G; Walters, GB; TAG Consortium, ; Oxford-GSK Consortium, ; ENGAGE consortium, ; Furberg, H; Sullivan, PF; Marchini, J; McCarthy, MI; Steinthorsdottir, V; Thorsteinsdottir, U; Stefansson, K

Published Date

  • October 1, 2013

Published In

Volume / Issue

  • 3 /

Start / End Page

  • e308 -

PubMed ID

  • 24084939

Pubmed Central ID

  • PMC3818010

Electronic International Standard Serial Number (EISSN)

  • 2158-3188

Digital Object Identifier (DOI)

  • 10.1038/tp.2013.81


  • eng

Conference Location

  • United States