Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry


Journal Article

Urine samples from three children at different stages of chronic valproate therapy were partially purified using a cation exchange column. A signal consistent with either valproylcarnitine or octanoylcamitine was observed in one of these extracts by direct fast atom bombardment-mass spectrometry analysis. These isomeric acylcarnitines were synthesized, separated and characterized by thermospray high performance liquid chromatography-mass spectrometry. This new technique was then employed to positively identify intact valproyl-camitine in the patients' urine samples. The implications of this finding with regard to a mechanism to account for carnitine deficiency in patients receiving valproate are discussed. © 1985.

Full Text

Duke Authors

Cited Authors

  • Millington, DS; Bohan, TP; Roe, CR; Yergey, AL; Liberato, DJ

Published Date

  • January 15, 1985

Published In

Volume / Issue

  • 145 / 1

Start / End Page

  • 69 - 76

International Standard Serial Number (ISSN)

  • 0009-8981

Digital Object Identifier (DOI)

  • 10.1016/0009-8981(85)90020-8

Citation Source

  • Scopus