Current Appointments & Affiliations
Associate Professor of Medicine
·
2023 - Present
Medicine, Nephrology,
Medicine
Chief, Division of Nephrology
·
2025 - Present
Medicine, Nephrology,
Medicine
Member of Duke Molecular Physiology Institute
·
2019 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
APOL1 kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Journal Article Kidney Int · November 2025 In people of African ancestry, apolipoprotein L1 gene (APOL1) variants have been identified as causing increased risk of progressive chronic kidney disease (CKD). In April of 2024, Kidney Disease: Improving Global Outcomes (KDIGO) convened a Controversies ... Full text Link to item CiteA Human Glomerular Disease Atlas defines the APOL1-JAK-STAT feed forward loop in focal segmental glomerulosclerosis.
Journal Article medRxiv · September 19, 2025 To map transcriptional programs in rare glomerular diseases, single-nucleus RNA sequencing (snRNAseq) on kidney biopsies (N=120) from the Nephrotic Syndrome Study Network were integrated with snRNAseq and single-cell sequencing (scRNAseq) of reference kidn ... Full text Link to item CiteAlterations in DNA Methylation, Proteomic, and Metabolomic Profiles in African Ancestry Populations with APOL1 Risk Alleles.
Journal Article J Am Soc Nephrol · April 7, 2025 KEY POINTS: We aimed to elucidate potential methylation, proteomic, and metabolomic mechanisms by which APOL1 variants may be linked to kidney disease. We report distinct methylation profiling between APOL1 risk allele carriers and noncarriers, many near A ... Full text Link to item CiteRecent Grants
Maze Therapeutics MZE829-201: An Open-Label Phase 2 Study to Evaluate the Safety, Tolerability, and Effect on Albuminuria of MZE829 in Adults with Proteinuric Chronic Kidney Disease and the APOL1 High Risk Genotype
Clinical TrialPrincipal Investigator · Awarded by Maze Therapeutics · 2025 - 2030Endocrinology and Metabolism Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029Identification of Host-Specific Determinants of APOL1-associated COVAN
ResearchMentor · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2029View All Grants
Education, Training & Certifications
Yeshiva University, Albert Einstein College of Medicine ·
2009
Ph.D.
Yeshiva University, Albert Einstein College of Medicine ·
2009
M.D.