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Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI.

Publication ,  Journal Article
Zacà, D; Jovicich, J; Nadar, SR; Voyvodic, JT; Pillai, JJ
Published in: J Magn Reson Imaging
August 2014

PURPOSE: (i) to validate blood oxygenation level dependent (BOLD) breathhold cerebrovascular reactivity (BH CVR) mapping as an effective technique for potential detection of neurovascular uncoupling (NVU) in a cohort of patients with perirolandic low grade gliomas undergoing presurgical functional MRI (fMRI) for sensorimotor mapping, and (ii) to determine whether NVU potential, as assessed by BH CVR mapping, is prevalent in this tumor group. MATERIALS AND METHODS: We retrospectively evaluated 12 patients, with histological diagnosis of grade II glioma, who performed multiple motor tasks and a BH task. Sensorimotor activation maps and BH CVR maps were compared in two automatically defined regions of interest (ROIs), ipsilateral to the lesion (i.e., ipsilesional) and contralateral to the lesion (i.e., contralesional). RESULTS: Motor task mean T-value was significantly higher in the contralesional ROIs (6.00 ± 1.74 versus 4.34 ± 1.68; P = 0.00004) as well as the BH mean T-value (4.74 ± 2.30 versus 4.09 ± 2.50; P = 0.009). The number of active voxels was significantly higher in the contralesional ROIs (Z = 2.99; P = 0.03). Actual NVU prevalence was 75%. CONCLUSION: Presurgical sensorimotor fMRI mapping can be affected by NVU-related false negative activation in low grade gliomas (76% of analyzed tasks).

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Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

August 2014

Volume

40

Issue

2

Start / End Page

383 / 390

Location

United States

Related Subject Headings

  • Surgery, Computer-Assisted
  • Sensitivity and Specificity
  • Retrospective Studies
  • Reproducibility of Results
  • Preoperative Care
  • Oxygen Consumption
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Grading
  • Middle Aged
  • Male
 

Citation

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Zacà, D., Jovicich, J., Nadar, S. R., Voyvodic, J. T., & Pillai, J. J. (2014). Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI. J Magn Reson Imaging, 40(2), 383–390. https://doi.org/10.1002/jmri.24406
Zacà, Domenico, Jorge Jovicich, Sreenivasan R. Nadar, James T. Voyvodic, and Jay J. Pillai. “Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI.J Magn Reson Imaging 40, no. 2 (August 2014): 383–90. https://doi.org/10.1002/jmri.24406.
Zacà D, Jovicich J, Nadar SR, Voyvodic JT, Pillai JJ. Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI. J Magn Reson Imaging. 2014 Aug;40(2):383–90.
Zacà, Domenico, et al. “Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI.J Magn Reson Imaging, vol. 40, no. 2, Aug. 2014, pp. 383–90. Pubmed, doi:10.1002/jmri.24406.
Zacà D, Jovicich J, Nadar SR, Voyvodic JT, Pillai JJ. Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI. J Magn Reson Imaging. 2014 Aug;40(2):383–390.
Journal cover image

Published In

J Magn Reson Imaging

DOI

EISSN

1522-2586

Publication Date

August 2014

Volume

40

Issue

2

Start / End Page

383 / 390

Location

United States

Related Subject Headings

  • Surgery, Computer-Assisted
  • Sensitivity and Specificity
  • Retrospective Studies
  • Reproducibility of Results
  • Preoperative Care
  • Oxygen Consumption
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Grading
  • Middle Aged
  • Male