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Analysis of individual items on the attention-deficit/hyperactivity disorder symptom rating scale in children and adults: the effects of age and sex in pivotal trials of lisdexamfetamine dimesylate.

Publication ,  Journal Article
Weisler, RH; Adler, LA; Kollins, SH; Goodman, DW; Hamdani, M; Dirks, B; Childress, AC
Published in: Neuropsychiatr Dis Treat
2014

BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) symptom presentation across age and sex has not been fully elucidated. The present post hoc analyses qualitatively explored the baseline levels of ADHD symptomatology across subgroups in two clinical trials of children and adults with ADHD to elucidate differences in participant presentation. The response to treatment was examined to determine patterns of response among items of the ADHD Rating Scale IV. METHODS: Exploratory post hoc analyses of ADHD Rating Scale IV item scores were conducted on data from two 4-week placebo-controlled trials in children (6-12 years) and in adults (18-55 years) with ADHD. Baseline and endpoint mean item scores were determined for subgroups defined by age (6-9, 10-12, 18-39, and 40-55 years) and sex. RESULTS: The baseline mean item scores were generally numerically similar for all age-by-sex subgroups. The inattention (IA) items were numerically higher than hyperactivity/impulsivity (H/I) items among older children and adults. The endpoint mean item scores were numerically lower after lisdexamfetamine dimesylate treatment for IA and H/I items in all subgroups. CONCLUSION: These results suggest that regardless of age or sex, baseline IA and H/I symptom profiles were comparable; however, IA vs H/I symptoms were more severe in older participants. In all age-by-sex subgroups, IA and H/I symptoms appeared to decrease after active treatment.

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Published In

Neuropsychiatr Dis Treat

DOI

ISSN

1176-6328

Publication Date

2014

Volume

10

Start / End Page

1 / 12

Location

New Zealand

Related Subject Headings

  • Neurology & Neurosurgery
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

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Weisler, R. H., Adler, L. A., Kollins, S. H., Goodman, D. W., Hamdani, M., Dirks, B., & Childress, A. C. (2014). Analysis of individual items on the attention-deficit/hyperactivity disorder symptom rating scale in children and adults: the effects of age and sex in pivotal trials of lisdexamfetamine dimesylate. Neuropsychiatr Dis Treat, 10, 1–12. https://doi.org/10.2147/NDT.S47087
Weisler, Richard H., Lenard A. Adler, Scott H. Kollins, David W. Goodman, Mohamed Hamdani, Bryan Dirks, and Ann C. Childress. “Analysis of individual items on the attention-deficit/hyperactivity disorder symptom rating scale in children and adults: the effects of age and sex in pivotal trials of lisdexamfetamine dimesylate.Neuropsychiatr Dis Treat 10 (2014): 1–12. https://doi.org/10.2147/NDT.S47087.

Published In

Neuropsychiatr Dis Treat

DOI

ISSN

1176-6328

Publication Date

2014

Volume

10

Start / End Page

1 / 12

Location

New Zealand

Related Subject Headings

  • Neurology & Neurosurgery
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences