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Hostile takeover: fungal protein promotes host cell invasion.

Publication ,  Journal Article
Alspaugh, JA
Published in: J Clin Invest
January 2014

The ability to suppress the immune system has lead to great advances in transplant technology and treatment of autoimmune diseases. Unfortunately, the immunosuppression of these patients has led to the rise of opportunistic infections by organisms that are recalcitrant to current prophylactic strategies. One such example is the increase of mucormycosis, an invasive infection caused by filamentous fungi of the order Mucorales. In this issue of the JCI, Gebremariam and colleagues determined that spore coat homolog (CotH) proteins are required for angioinvasion and that these proteins are unique to Mucorales. Their findings provide a potential therapeutic target for prevention and treatment of mucormycosis.

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Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

January 2014

Volume

124

Issue

1

Start / End Page

74 / 76

Location

United States

Related Subject Headings

  • Rhizopus
  • Mucormycosis
  • Male
  • Immunology
  • Humans
  • Fungal Proteins
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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ICMJE
MLA
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Alspaugh, J. A. (2014). Hostile takeover: fungal protein promotes host cell invasion. J Clin Invest, 124(1), 74–76. https://doi.org/10.1172/JCI73585
Alspaugh, J Andrew. “Hostile takeover: fungal protein promotes host cell invasion.J Clin Invest 124, no. 1 (January 2014): 74–76. https://doi.org/10.1172/JCI73585.
Alspaugh JA. Hostile takeover: fungal protein promotes host cell invasion. J Clin Invest. 2014 Jan;124(1):74–6.
Alspaugh, J. Andrew. “Hostile takeover: fungal protein promotes host cell invasion.J Clin Invest, vol. 124, no. 1, Jan. 2014, pp. 74–76. Pubmed, doi:10.1172/JCI73585.
Alspaugh JA. Hostile takeover: fungal protein promotes host cell invasion. J Clin Invest. 2014 Jan;124(1):74–76.

Published In

J Clin Invest

DOI

EISSN

1558-8238

Publication Date

January 2014

Volume

124

Issue

1

Start / End Page

74 / 76

Location

United States

Related Subject Headings

  • Rhizopus
  • Mucormycosis
  • Male
  • Immunology
  • Humans
  • Fungal Proteins
  • Animals
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences