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Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability.

Publication ,  Journal Article
Murugan, M; Harward, S; Scharff, C; Mooney, R
Published in: Neuron
December 18, 2013

Mutations of the FOXP2 gene impair speech and language development in humans and shRNA-mediated suppression of the avian ortholog FoxP2 disrupts song learning in juvenile zebra finches. How diminished FoxP2 levels affect vocal control and alter the function of neural circuits important to learned vocalizations remains unclear. Here we show that FoxP2 knockdown in the songbird striatum disrupts developmental and social modulation of song variability. Recordings in anesthetized birds show that FoxP2 knockdown interferes with D1R-dependent modulation of activity propagation in a corticostriatal pathway important to song variability, an effect that may be partly attributable to reduced D1R and DARPP-32 protein levels. Furthermore, recordings in singing birds reveal that FoxP2 knockdown prevents social modulation of singing-related activity in this pathway. These findings show that reduced FoxP2 levels interfere with the dopaminergic modulation of vocal variability, which may impede song and speech development by disrupting reinforcement learning mechanisms.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 18, 2013

Volume

80

Issue

6

Start / End Page

1464 / 1476

Location

United States

Related Subject Headings

  • Zebrafish Proteins
  • Vocalization, Animal
  • Social Behavior
  • Receptors, Dopamine D1
  • Neurology & Neurosurgery
  • Neural Pathways
  • Male
  • Learning
  • Gene Knockdown Techniques
  • Gene Expression Regulation, Developmental
 

Citation

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Murugan, M., Harward, S., Scharff, C., & Mooney, R. (2013). Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability. Neuron, 80(6), 1464–1476. https://doi.org/10.1016/j.neuron.2013.09.021
Murugan, Malavika, Stephen Harward, Constance Scharff, and Richard Mooney. “Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability.Neuron 80, no. 6 (December 18, 2013): 1464–76. https://doi.org/10.1016/j.neuron.2013.09.021.
Murugan M, Harward S, Scharff C, Mooney R. Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability. Neuron. 2013 Dec 18;80(6):1464–76.
Murugan, Malavika, et al. “Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability.Neuron, vol. 80, no. 6, Dec. 2013, pp. 1464–76. Pubmed, doi:10.1016/j.neuron.2013.09.021.
Murugan M, Harward S, Scharff C, Mooney R. Diminished FoxP2 levels affect dopaminergic modulation of corticostriatal signaling important to song variability. Neuron. 2013 Dec 18;80(6):1464–1476.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 18, 2013

Volume

80

Issue

6

Start / End Page

1464 / 1476

Location

United States

Related Subject Headings

  • Zebrafish Proteins
  • Vocalization, Animal
  • Social Behavior
  • Receptors, Dopamine D1
  • Neurology & Neurosurgery
  • Neural Pathways
  • Male
  • Learning
  • Gene Knockdown Techniques
  • Gene Expression Regulation, Developmental