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Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning.

Publication ,  Journal Article
Yang, Y; Lisberger, SG
Published in: Elife
December 31, 2013

Motor learning occurs through interactions between the cerebellar circuit and cellular plasticity at different sites. Previous work has established plasticity in brain slices and suggested plausible sites of behavioral learning. We now reveal what actually happens in the cerebellum during short-term learning. We monitor the expression of plasticity in the simple-spike firing of cerebellar Purkinje cells during trial-over-trial learning in smooth pursuit eye movements of monkeys. Our findings imply that: 1) a single complex-spike response driven by one instruction for learning causes short-term plasticity in a Purkinje cell's mossy fiber/parallel-fiber input pathways; 2) complex-spike responses and simple-spike firing rate are correlated across the Purkinje cell population; and 3) simple-spike firing rate at the time of an instruction for learning modulates the probability of a complex-spike response, possibly through a disynaptic feedback pathway to the inferior olive. These mechanisms may participate in long-term motor learning. DOI: http://dx.doi.org/10.7554/eLife.01574.001.

Duke Scholars

Published In

Elife

DOI

ISSN

2050-084X

Publication Date

December 31, 2013

Volume

2

Start / End Page

e01574

Location

England

Related Subject Headings

  • Purkinje Cells
  • Neuronal Plasticity
  • Male
  • Macaca mulatta
  • Learning
  • Eye Movements
  • Cerebellum
  • Behavior, Animal
  • Animals
  • Action Potentials
 

Citation

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MLA
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Yang, Y., & Lisberger, S. G. (2013). Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning. Elife, 2, e01574. https://doi.org/10.7554/eLife.01574
Yang, Yan, and Stephen G. Lisberger. “Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning.Elife 2 (December 31, 2013): e01574. https://doi.org/10.7554/eLife.01574.
Yang, Yan, and Stephen G. Lisberger. “Interaction of plasticity and circuit organization during the acquisition of cerebellum-dependent motor learning.Elife, vol. 2, Dec. 2013, p. e01574. Pubmed, doi:10.7554/eLife.01574.

Published In

Elife

DOI

ISSN

2050-084X

Publication Date

December 31, 2013

Volume

2

Start / End Page

e01574

Location

England

Related Subject Headings

  • Purkinje Cells
  • Neuronal Plasticity
  • Male
  • Macaca mulatta
  • Learning
  • Eye Movements
  • Cerebellum
  • Behavior, Animal
  • Animals
  • Action Potentials