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Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes.

Publication ,  Journal Article
Kearse, KP; Roberts, JP; Wiest, DL; Singer, A
Published in: Bioessays
December 1995

Most lymphocytes of the T cell lineage develop along the CD4/CD8 pathway and express antigen receptors on their surfaces consisting of clonotypic alpha beta chains associated with invariant CD3- gamma delta epsilon components and sigma chains, collectively referred to as the T cell antigen receptor complex (TCR). Expression of the TCR complex is dynamically regulated during T cell development, with immature CD4+CD8+ thymocytes expressing only 10% of the number of alpha beta TCR complexes on their surfaces expressed by mature CD4+ and CD8+ T cells. Recent evidence demonstrates that low surface TCR density on CD4+CD8+ thymocytes results from the limited survival of a single TCR component within the ER, the TCR alpha chain, which as a half life of only 15 minutes in immature thymocytes, compared to >75 minutes in mature T cells. Instability of TCR alpha proteins in immature CD4+CD8+ thymocytes represents a novel mechanism by which expression of the multisubunit TCR complex is quantitatively regulated during T cell development. In the current review we discuss our recent findings concerning the assembly, intracellular transport, and expression of alpha beta TCR complexes in CD4+CD8+ thymocytes and comment on the functional significance of TCR alpha instability during T cell development.

Duke Scholars

Published In

Bioessays

DOI

ISSN

0265-9247

Publication Date

December 1995

Volume

17

Issue

12

Start / End Page

1049 / 1054

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocyte Subsets
  • Receptors, Antigen, T-Cell, alpha-beta
  • Humans
  • Developmental Biology
  • CD8 Antigens
  • CD4 Antigens
  • Animals
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kearse, K. P., Roberts, J. P., Wiest, D. L., & Singer, A. (1995). Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes. Bioessays, 17(12), 1049–1054. https://doi.org/10.1002/bies.950171209
Kearse, K. P., J. P. Roberts, D. L. Wiest, and A. Singer. “Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes.Bioessays 17, no. 12 (December 1995): 1049–54. https://doi.org/10.1002/bies.950171209.
Kearse KP, Roberts JP, Wiest DL, Singer A. Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes. Bioessays. 1995 Dec;17(12):1049–54.
Kearse, K. P., et al. “Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes.Bioessays, vol. 17, no. 12, Dec. 1995, pp. 1049–54. Pubmed, doi:10.1002/bies.950171209.
Kearse KP, Roberts JP, Wiest DL, Singer A. Developmental regulation of alpha beta T cell antigen receptor assembly in immature CD4+CD8+ thymocytes. Bioessays. 1995 Dec;17(12):1049–1054.
Journal cover image

Published In

Bioessays

DOI

ISSN

0265-9247

Publication Date

December 1995

Volume

17

Issue

12

Start / End Page

1049 / 1054

Location

United States

Related Subject Headings

  • Thymus Gland
  • T-Lymphocyte Subsets
  • Receptors, Antigen, T-Cell, alpha-beta
  • Humans
  • Developmental Biology
  • CD8 Antigens
  • CD4 Antigens
  • Animals
  • 31 Biological sciences
  • 17 Psychology and Cognitive Sciences