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Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results.

Publication ,  Journal Article
Yang, J; Cai, J; Wang, H; Chang, Z; Czito, BG; Bashir, MR; Yin, F-F
Published in: Int J Radiat Oncol Biol Phys
March 15, 2014

PURPOSE: To evaluate the feasibility of a retrospective binning technique for 4-dimensional magnetic resonance imaging (4D-MRI) using body area (BA) as a respiratory surrogate. METHODS AND MATERIALS: Seven patients with hepatocellular carcinoma (4 of 7) or liver metastases (3 of 7) were enrolled in an institutional review board-approved prospective study. All patients were simulated with both computed tomography (CT) and MRI to acquire 3-dimensional and 4D images for treatment planning. Multiple-slice multiple-phase cine-MR images were acquired in the axial plane for 4D-MRI reconstruction. Image acquisition time per slice was set to 10-15 seconds. Single-slice 2-dimensional cine-MR images were also acquired across the center of the tumor in orthogonal planes. Tumor motion trajectories from 4D-MRI, cine-MRI, and 4D-CT were analyzed in the superior-inferior (SI), anterior-posterior (AP), and medial-lateral (ML) directions, respectively. Their correlation coefficients (CC) and differences in tumor motion amplitude were determined. Tumor-to-liver contrast-to-noise ratio (CNR) was measured and compared between 4D-CT, 4D-MRI, and conventional T2-weighted fast spin echo MRI. RESULTS: The means (± standard deviations) of CC comparing 4D-MRI with cine-MRI were 0.97 ± 0.03, 0.97 ± 0.02, and 0.99 ± 0.04 in SI, AP, and ML directions, respectively. The mean differences were 0.61 ± 0.17 mm, 0.32 ± 0.17 mm, and 0.14 ± 0.06 mm in SI, AP, and ML directions, respectively. The means of CC comparing 4D-MRI and 4D-CT were 0.95 ± 0.02, 0.94 ± 0.02, and 0.96 ± 0.02 in SI, AP, and ML directions, respectively. The mean differences were 0.74 ± 0.02 mm, 0.33 ± 0.13 mm, and 0.18 ± 0.07 mm in SI, AP, and ML directions, respectively. The mean tumor-to-tissue CNRs were 2.94 ± 1.51, 19.44 ± 14.63, and 39.47 ± 20.81 in 4D-CT, 4D-MRI, and T2-weighted MRI, respectively. CONCLUSIONS: The preliminary evaluation of our 4D-MRI technique results in oncologic patients demonstrates its potential usefulness to accurately measure tumor respiratory motion with improved tumor CNR compared with 4D-CT.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

March 15, 2014

Volume

88

Issue

4

Start / End Page

907 / 912

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Respiration
  • Oncology & Carcinogenesis
  • Movement
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Image Processing, Computer-Assisted
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yang, J., Cai, J., Wang, H., Chang, Z., Czito, B. G., Bashir, M. R., & Yin, F.-F. (2014). Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results. Int J Radiat Oncol Biol Phys, 88(4), 907–912. https://doi.org/10.1016/j.ijrobp.2013.11.245
Yang, Juan, Jing Cai, Hongjun Wang, Zheng Chang, Brian G. Czito, Mustafa R. Bashir, and Fang-Fang Yin. “Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results.Int J Radiat Oncol Biol Phys 88, no. 4 (March 15, 2014): 907–12. https://doi.org/10.1016/j.ijrobp.2013.11.245.
Yang J, Cai J, Wang H, Chang Z, Czito BG, Bashir MR, et al. Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results. Int J Radiat Oncol Biol Phys. 2014 Mar 15;88(4):907–12.
Yang, Juan, et al. “Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results.Int J Radiat Oncol Biol Phys, vol. 88, no. 4, Mar. 2014, pp. 907–12. Pubmed, doi:10.1016/j.ijrobp.2013.11.245.
Yang J, Cai J, Wang H, Chang Z, Czito BG, Bashir MR, Yin F-F. Four-dimensional magnetic resonance imaging using axial body area as respiratory surrogate: initial patient results. Int J Radiat Oncol Biol Phys. 2014 Mar 15;88(4):907–912.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

March 15, 2014

Volume

88

Issue

4

Start / End Page

907 / 912

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Respiration
  • Oncology & Carcinogenesis
  • Movement
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging, Cine
  • Magnetic Resonance Imaging
  • Liver Neoplasms
  • Image Processing, Computer-Assisted