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Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer.

Publication ,  Journal Article
Yang, Y; Catalano, S; Kelsey, CR; Yoo, DS; Yin, F-F; Cai, J
Published in: Med Dosim
2014

To quantitatively evaluate dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer. Overall, 11 lung SBRT patients (8 female and 3 male; mean age: 75.0 years) with medially located tumors were included. Treatment plans with simulated rotational offsets of 1°, 3°, and 5° in roll, yaw, and pitch were generated and compared with the original plans. Both clockwise and counterclockwise rotations were investigated. The following dosimetric metrics were quantitatively evaluated: planning target volume coverage (PTV V100%), max PTV dose (PTV Dmax), percentage prescription dose to 0.35cc of cord (cord D0.35cc), percentage prescription dose to 0.35cc and 5cc of esophagus (esophagus D0.35cc and D5cc), and volume of the lungs receiving at least 20Gy (lung V20). Statistical significance was tested using Wilcoxon signed rank test at the significance level of 0.05. Overall, small differences were found in all dosimetric matrices at all rotational offsets: 95.6% of differences were < 1% or < 1Gy. Of all rotational offsets, largest change in PTV V100%, PTV Dmax, cord D0.35cc, esophagus D0.35cc, esophagus D5cc, and lung V20 was - 8.36%, - 6.06%, 11.96%, 8.66%, 6.02%, and - 0.69%, respectively. No significant correlation was found between any dosimetric change and tumor-to-cord/esophagus distances (R(2) range: 0 to 0.44). Larger dosimetric changes and intersubject variations were observed at larger rotational offsets. Small dosimetric differences were found owing to rotational offsets up to 5° in lung SBRT for medially located tumors. Larger intersubject variations were observed at larger rotational offsets.

Duke Scholars

Published In

Med Dosim

DOI

EISSN

1873-4022

Publication Date

2014

Volume

39

Issue

1

Start / End Page

117 / 121

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sensitivity and Specificity
  • Rotation
  • Reproducibility of Results
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiosurgery
  • Patient Positioning
  • Oncology & Carcinogenesis
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Yang, Y., Catalano, S., Kelsey, C. R., Yoo, D. S., Yin, F.-F., & Cai, J. (2014). Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer. Med Dosim, 39(1), 117–121. https://doi.org/10.1016/j.meddos.2013.11.002
Yang, Yun, Suzanne Catalano, Chris R. Kelsey, David S. Yoo, Fang-Fang Yin, and Jing Cai. “Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer.Med Dosim 39, no. 1 (2014): 117–21. https://doi.org/10.1016/j.meddos.2013.11.002.
Yang Y, Catalano S, Kelsey CR, Yoo DS, Yin F-F, Cai J. Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer. Med Dosim. 2014;39(1):117–21.
Yang, Yun, et al. “Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer.Med Dosim, vol. 39, no. 1, 2014, pp. 117–21. Pubmed, doi:10.1016/j.meddos.2013.11.002.
Yang Y, Catalano S, Kelsey CR, Yoo DS, Yin F-F, Cai J. Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer. Med Dosim. 2014;39(1):117–121.
Journal cover image

Published In

Med Dosim

DOI

EISSN

1873-4022

Publication Date

2014

Volume

39

Issue

1

Start / End Page

117 / 121

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Sensitivity and Specificity
  • Rotation
  • Reproducibility of Results
  • Radiotherapy Planning, Computer-Assisted
  • Radiotherapy Dosage
  • Radiosurgery
  • Patient Positioning
  • Oncology & Carcinogenesis
  • Middle Aged