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Precuneus is a functional core of the default-mode network.

Publication ,  Journal Article
Utevsky, AV; Smith, DV; Huettel, SA
Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
January 2014

Efforts to understand the functional architecture of the brain have consistently identified multiple overlapping large-scale neural networks that are observable across multiple states. Despite the ubiquity of these networks, it remains unclear how regions within these large-scale neural networks interact to orchestrate behavior. Here, we collected functional magnetic resonance imaging data from 188 human subjects who engaged in three cognitive tasks and a resting-state scan. Using multiple tasks and a large sample allowed us to use split-sample validations to test for replication of results. We parceled the task-rest pairs into functional networks using a probabilistic spatial independent components analysis. We examined changes in connectivity between task and rest states using dual-regression analysis, which quantifies voxelwise connectivity estimates for each network of interest while controlling for the influence of signals arising from other networks and artifacts. Our analyses revealed systematic state-dependent functional connectivity in one brain region: the precuneus. Specifically, task performance led to increased connectivity (compared to rest) between the precuneus and the left frontoparietal network (lFPN), whereas rest increased connectivity between the precuneus and the default-mode network (DMN). The absolute magnitude of this effect was greater for DMN, suggesting a heightened specialization for resting-state cognition. All results replicated within the two independent samples. Our results indicate that the precuneus plays a core role not only in DMN, but also more broadly through its engagement under a variety of processing states.

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Published In

The Journal of neuroscience : the official journal of the Society for Neuroscience

DOI

EISSN

1529-2401

ISSN

0270-6474

Publication Date

January 2014

Volume

34

Issue

3

Start / End Page

932 / 940

Related Subject Headings

  • Rest
  • Reaction Time
  • Psychomotor Performance
  • Photic Stimulation
  • Neurology & Neurosurgery
  • Nerve Net
  • Male
  • Humans
  • Female
  • Brain Mapping
 

Citation

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ICMJE
MLA
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Utevsky, A. V., Smith, D. V., & Huettel, S. A. (2014). Precuneus is a functional core of the default-mode network. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 34(3), 932–940. https://doi.org/10.1523/jneurosci.4227-13.2014
Utevsky, Amanda V., David V. Smith, and Scott A. Huettel. “Precuneus is a functional core of the default-mode network.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 34, no. 3 (January 2014): 932–40. https://doi.org/10.1523/jneurosci.4227-13.2014.
Utevsky AV, Smith DV, Huettel SA. Precuneus is a functional core of the default-mode network. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Jan;34(3):932–40.
Utevsky, Amanda V., et al. “Precuneus is a functional core of the default-mode network.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol. 34, no. 3, Jan. 2014, pp. 932–40. Epmc, doi:10.1523/jneurosci.4227-13.2014.
Utevsky AV, Smith DV, Huettel SA. Precuneus is a functional core of the default-mode network. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Jan;34(3):932–940.

Published In

The Journal of neuroscience : the official journal of the Society for Neuroscience

DOI

EISSN

1529-2401

ISSN

0270-6474

Publication Date

January 2014

Volume

34

Issue

3

Start / End Page

932 / 940

Related Subject Headings

  • Rest
  • Reaction Time
  • Psychomotor Performance
  • Photic Stimulation
  • Neurology & Neurosurgery
  • Nerve Net
  • Male
  • Humans
  • Female
  • Brain Mapping